Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTHBDA9)

• DTT Name: X-linked retinitis pigmentosa GTPase regulator (RPGR) DTT Info
• Gene Name: RPGR

Molecule-Related Drug & Molecule List

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIIB112	DMDY7RR	X-linked retinitis pigmentosa	9B70	Phase 3	[1]
BIIB-088	DMUSJ3D	Retinitis pigmentosa	9B70	Phase 2/3	[2]
AAV-RPGR	DM7TF49	Retinitis pigmentosa	9B70	Phase 1/2	[3]
AGTC-501	DMTS51C	Retinitis pigmentosa	9B70	Phase 1/2	[4]

References

• [1] Changes in Retinal Sensitivity Associated With Cotoretigene Toliparvovec in X-Linked Retinitis Pigmentosa With RPGR Gene Variations. JAMA Ophthalmol. 2023 Mar 1;141(3):275-283.
• [2] ClinicalTrials.gov (NCT04850118) A Clinical Trial Evaluating the Safety and Efficacy of a Single Subretinal Injection of AGTC-501 in Participants With X-linked Retinitis Pigmentosa Caused by RPGR Mutations. U.S. National Institutes of Health.
• [3] Clinical pipeline report, company report or official report of MeiraGTx.
• [4] ClinicalTrials.gov (NCT03316560) Safety and Efficacy of rAAV2tYF-GRK1-RPGR in Subjects With X-linked Retinitis Pigmentosa Caused by RPGR Mutations. U.S. National Institutes of Health.