Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTHCF4J)

• DTT Name: Alpha-glucosidase (GLA) DTT Info
• Gene Name: GAA

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cipaglucosidase alfa	DMAPDH2	Glycogen storage disease type II	5C51.3	Approved in EU	[1]

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Anamorelin	DM6HXTS	Carbohydrate metabolism disorder	5C51.Z	Phase 3	[2]
Deoxynojirimycin	DM2ATZB	Pompe disease	5C51.3	Phase 3	[3]
Maltose	DMH0ROP	N. A.	N. A.	Phase 1/2	[4]
AAV2/8-LSPhGAA	DMIX5HF	Pompe disease	5C51.3	Phase 1	[5]

8 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
4,6-Dideoxyglucose	DMP5M9E	Discovery agent	N.A.	Investigative	[6]
6-Deoxy-Alpha-D-Glucose	DM9HBY5	Discovery agent	N.A.	Investigative	[6]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[6]
Double Oxidized Cysteine	DM6TU84	Discovery agent	N.A.	Investigative	[6]
JBP-1	DM0KMPN	Solid tumour/cancer	2A00-2F9Z	Investigative	[7]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[6]
POP-1	DMVTKCX	Solid tumour/cancer	2A00-2F9Z	Investigative	[7]
Tendamistat	DML53GP	Discovery agent	N.A.	Investigative	[8]

References

• [1] Cipaglucosidase Alfa: First Approval. Drugs. 2023 Jun;83(8):739-745.
• [2] Absorption, elimination, and metabolism of CS-1036, a novel -amylase inhibitor in rats and monkeys, and the relationship between gastrointestinal distribution and suppression of glucose absorption.Drug Metab Dispos.2013 Apr;41(4):878-87.
• [3] Nitrogen-in-the-ring pyranoses and furanoses: structural basis of inhibition of mammalian glycosidases. J Med Chem. 1994 Oct 28;37(22):3701-6.
• [4] DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-41.
• [5] ClinicalTrials.gov (NCT03533673) AAV2/8-LSPhGAA in Late-Onset Pompe Disease. U.S. National Institutes of Health.
• [6] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [7] US patent application no. 2012,0251,516, PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING TRYPSINOGEN AND/OR CHYMOTRYPSINOGEN AND AN ACTIVE AGENT SELECTED FROM A SELENIUM COMPOUND, A VANILLOID COMPOUND AND A CYTOPLASMIC GLYCOLYSIS REDUCTION AGENT.
• [8] Influence of Specific Signal Peptide Mutations on the Expression and Secretion of the alpha -Amylase Inhibitor Tendamistat in Streptomyces lividans. J Biol Chem. 1996 Jun 21;271(25):15244-52.