Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTHPFTS)

• DTT Name: Plasmodium Beta-hydroxyacyl-ACP dehydratase (Malaria FabZ) DTT Info
• Gene Name: Malaria FabZ

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[1]

6 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(-)-CATECHINGALLATE	DMZOGSK	Discovery agent	N.A.	Investigative	[1]
2-Hexadecynoic acid	DMTFIPZ	Discovery agent	N.A.	Investigative	[2]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[1]
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[1]
GALLOCATECHIN GALLATE	DMX2084	Discovery agent	N.A.	Investigative	[1]
MORIN	DM2OGZ5	Discovery agent	N.A.	Investigative	[1]

References

• [1] Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem. 2006 Jun 1;49(11):3345-53.
• [2] 2-Hexadecynoic acid inhibits plasmodial FAS-II enzymes and arrests erythrocytic and liver stage Plasmodium infections. Bioorg Med Chem. 2010 Nov 1;18(21):7475-85.