General Information of DTT (ID: TTMWT8Z)

DTT Name C-X-C chemokine receptor type 1 (CXCR1) DTT Info
Gene Name CXCR1

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
1 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [1]
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3 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Reparixin DMVBA7I Pancreatic islet transplantation failure NE84 Phase 3 [1]
SCH-527123 DMPUAOE Chronic obstructive pulmonary disease CA22 Phase 2 [2]
SX-682 DMHMG6X Melanoma 2C30 Phase 1 [3]
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2 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
INDOPROFEN DM5QSKN Gout FA25 Withdrawn from market [1]
R-ketoprofen DMHSUQ1 N. A. N. A. Discontinued in Phase 2 [1]
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12 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(R)-2-(4-Isobutyl-phenyl)-N-methoxy-propionamide DMR8E0G Discovery agent N.A. Investigative [1]
(R)-2-(4-Isobutyl-phenyl)-propionamide DMBQ0PR Discovery agent N.A. Investigative [1]
(R)-3-(4-Isobutyl-phenyl)-butan-2-one DMQ2KF8 Discovery agent N.A. Investigative [1]
(R)-N-Hydroxy-2-(4-isobutyl-phenyl)-propionamide DMWRIQG Discovery agent N.A. Investigative [1]
1-(2-Bromo-phenyl)-3-(2,4-dihydroxy-phenyl)-urea DMUSEOW Discovery agent N.A. Investigative [4]
1-(2-hydroxy-4-nitrophenyl)-3-phenylurea DMN4G7U Discovery agent N.A. Investigative [5]
2-(3-Isobutyl-phenyl)-propionic acid DM59VBG Discovery agent N.A. Investigative [1]
2-(3-Isopropyl-phenyl)-propionic acid DMUOWNE Discovery agent N.A. Investigative [1]
2-[3-(1-Hydroxy-propyl)-phenyl]-propionic acid DMDT9KG Discovery agent N.A. Investigative [1]
2-[3-(1-Phenyl-ethyl)-phenyl]-propionic acid DMWIUR0 Discovery agent N.A. Investigative [1]
2-[3-(2-Methyl-butyl)-phenyl]-propionic acid DMKSDT4 Discovery agent N.A. Investigative [1]
Il-8((3-73))K11R DM10Z5W Discovery agent N.A. Investigative [6]
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⏷ Show the Full List of 12 Investigative Drug(s)
Molecule Interaction Atlas

References

1 2-Arylpropionic CXC chemokine receptor 1 (CXCR1) ligands as novel noncompetitive CXCL8 inhibitors. J Med Chem. 2005 Jun 30;48(13):4312-31.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models. Clin Cancer Res. 2020 Mar 15;26(6):1420-1431.
4 Synthesis and structure-activity relationships of 3,5-diarylisoxazoles and 3,5-diaryl-1,2,4-oxadiazoles, novel classes of small molecule interleuki... Bioorg Med Chem Lett. 2004 Aug 16;14(16):4307-11.
5 Evaluation of potent and selective small-molecule antagonists for the CXCR2 chemokine receptor. J Med Chem. 2004 Mar 11;47(6):1319-21.
6 Il-8((3-73))K11R is a high affinity agonist of the neutrophil CXCR1 and CXCR2. Biochem Biophys Res Commun. 2001 Aug 24;286(3):595-600.