General Information of DTT (ID: TTN53ZF)

DTT Name Leukotriene B4 receptor 1 (LTB4R) DTT Info
Gene Name LTB4R

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
3 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amelubant DMUMCB9 Pulmonary disease 1B10-1F85 Phase 2 [1]
LTB4 DME26RS Human immunodeficiency virus infection 1C62 Phase 2 [2]
Biomed 101 DMQ9KZW Kidney cancer 2C90.0 Phase 1 [3]
------------------------------------------------------------------------------------
21 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
CI-949 DMN4QSW Asthma CA23 Discontinued in Phase 2 [4]
CP-195543 DM1OSUR Rheumatoid arthritis FA20 Discontinued in Phase 2 [5]
LTB 019 DM6G0PN Asthma CA23 Discontinued in Phase 2 [6]
LY-223982 DMWB7DO Asthma CA23 Discontinued in Phase 2 [7]
LY293111 DM03FHA Pancreatic cancer 2C10 Discontinued in Phase 2 [8]
SB-201993 DMIF4VJ Psoriasis vulgaris EA90 Discontinued in Phase 2 [9]
CP-105696 DM1C4IN Inflammatory bowel disease DD72 Discontinued in Phase 1 [10]
TAK-683 DMRD8HK Prostate cancer 2C82.0 Discontinued in Phase 1 [11]
DW-1350 DM3L0T1 Osteoporosis FB83.0 Terminated [12]
LY-210073 DMUEB4P Asthma CA23 Terminated [13]
LY-255283 DMFIR0S Asthma CA23 Terminated [14]
LY-292728 DMU24HR N. A. N. A. Terminated [15]
RG-14893 DMKFQC7 Asthma CA23 Terminated [16]
Ro-25-4094 DMVB0C3 Inflammation 1A00-CA43.1 Terminated [17]
RP-66153 DMX4E75 Asthma CA23 Terminated [18]
RP-66364 DM6HJX7 Inflammation 1A00-CA43.1 Terminated [19]
RP-69698 DMUY4FD Inflammation 1A00-CA43.1 Terminated [20]
SB-201146 DMGNZUX N. A. N. A. Terminated [9]
SB-209247 DMVBNTP Psoriasis vulgaris EA90 Terminated [21]
SC-51146 DMI0QZ3 N. A. N. A. Terminated [22]
SC-53228 DMSKHGQ Asthma CA23 Terminated [22]
------------------------------------------------------------------------------------
⏷ Show the Full List of 21 Discontinued Drug(s)
13 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
(3S,4R)-3-Benzyl-7-isopropyl-chroman-4-ol DMET6IS Discovery agent N.A. Investigative [10]
(LTB4-(Csa)4)2-Glu-H Conjugate DMRGIF3 Discovery agent N.A. Investigative [23]
DTPA Conjugate DMNS265 Discovery agent N.A. Investigative [23]
HYNIC Analogue DMETS37 Discovery agent N.A. Investigative [23]
Leucettamidine DM94JXH Discovery agent N.A. Investigative [24]
LEUCETTAMINE A DMIZVA6 Discovery agent N.A. Investigative [24]
LY-282210 DMBSFDE Discovery agent N.A. Investigative [15]
SC-50073 DMU2WIS Discovery agent N.A. Investigative [22]
SC-50135 DMI2KE7 Discovery agent N.A. Investigative [22]
SC-50676 DM8RJ0V Discovery agent N.A. Investigative [22]
SC-52073 DM0E2SM Discovery agent N.A. Investigative [22]
SC-52569 DMLOJ42 Discovery agent N.A. Investigative [22]
SC-53229 DMYH12X Discovery agent N.A. Investigative [22]
------------------------------------------------------------------------------------
⏷ Show the Full List of 13 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Leukotriene receptor antagonists in children with cystic fibrosis lung disease : anti-inflammatory and clinical effects. Paediatr Drugs. 2005;7(6):353-63.
2 LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes. Nat Med. 2015 Mar;21(3):239-47.
3 Biomed 101, a leukotriene B4 inhibitor, may decrease IL-2 toxicity. 2003 ASCO Annual Meeting. 2003.
4 Inhibition of histamine, leukotriene C4/D4, and thromboxane B2 release from human leukocytes and human chopped lung mast cells by the allergic mediator release inhibitor, CI-949. J Allergy Clin Immunol. 1990 Dec;86(6 Pt 1):902-8.
5 The synthesis of CP-195543, an LTB4 antagonist for the treatment of inflammatory diseases. Curr Opin Drug Discov Devel. 1999 Nov;2(6):550-6.
6 Effect of the oral leukotriene B4 receptor antagonist LTB019 on inflammatory sputum markers in patients with chronic obstructive pulmonary disease. Pulm Pharmacol Ther. 2008;21(2):409-17.
7 Specific inhibition of leukotriene B4-induced neutrophil activation by LY223982. J Pharmacol Exp Ther. 1992 Dec;263(3):1009-14.
8 The Role of PPARgamma Receptors and Leukotriene B(4) Receptors in Mediating the Effects of LY293111 in Pancreatic Cancer. PPAR Res. 2008;2008:827096.
9 (E)-3-[6-[[(2,6-dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2- pyridinyl]-2-propenoic acid: a high-affinity leukotriene B4 receptor antagonist w... J Med Chem. 1996 Sep 13;39(19):3837-41.
10 3-Substituted-4-hydroxy-7-chromanylacetic acid derivatives as antagonists of the leukotriene B4 (LTB4) receptor, Bioorg. Med. Chem. Lett. 7(17):2307-2312 (1997).
11 A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J Exp Med. 2000 Aug 7;192(3):421-32.
12 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026850)
13 Design, synthesis, and pharmacological evaluation of potent xanthone dicarboxylic acid leukotriene B4 receptor antagonists. J Med Chem. 1993 Jun 11;36(12):1726-34.
14 o-phenylphenols: potent and orally active leukotriene B4 receptor antagonists. J Med Chem. 1993 Nov 26;36(24):3978-81.
15 Biphenylyl-substituted xanthones: highly potent leukotriene B4 receptor antagonists. J Med Chem. 1993 Nov 26;36(24):3982-4.
16 Structure-activity relationships study of two series of leukotriene B4 antagonists: novel indolyl and naphthyl compounds substituted with a 2-[methyl(2-phenethyl)amino]-2-oxoethyl side chain. J Med Chem. 1996 Sep 13;39(19):3756-68.
17 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800005401)
18 Omega-[(omega-arylalkyl)thienyl]alkanoic acids: from specific LTA4 hydrolase inhibitors to LTB4 receptor antagonists. J Med Chem. 1992 Aug 21;35(17):3170-9.
19 WO patent application no. 1997,0297,75, Compositions comprising a cyclooxygenase-2 inhibitor and a leukotriene b4 receptor antagonist.
20 omega-[(4,6-Diphenyl-2-pyridyl)oxy]alkanoic acid derivatives: a new family of potent and orally active LTB4 antagonists. J Med Chem. 1992 Nov 13;35(23):4315-24.
21 Formation and protein binding of the acyl glucuronide of a leukotriene B4 antagonist (SB-209247): relation to species differences in hepatotoxicity. Drug Metab Dispos. 2005 Feb;33(2):271-81.
22 Synthesis and pharmacological activity of SC-53228, a leukotriene B4 receptor antagonist with high intrinsic potency and selectivity, Bioorg. Med. Chem. Lett. 4(6):811-816 (1994).
23 Synthesis of leukotriene B4 antagonists labeled with In-111 or Tc-99m to image infectious and inflammatory foci. J Med Chem. 2005 Oct 6;48(20):6442-53.
24 New leukotriene B4 receptor antagonist: leucettamine A and related imidazole alkaloids from the marine sponge Leucetta microraphis. J Nat Prod. 1993 Jan;56(1):116-21.