Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTNGJPH)

• DTT Name: Beta-galactosidase (GLB1) DTT Info
• Gene Name: GLB1

Molecule-Related Drug & Molecule List

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AXO-AAV-GM1	DMFBMI7	GM1 gangliosidosis	5C56.00	Phase 1/2	[1]
LYS-GM-101	DMPD79C	GM1 gangliosidosis	5C56.00	Phase 1/2	[2]
PBGM01	DMNJEGV	GM1 gangliosidosis	5C56.00	Phase 1/2	[3]

2 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
5N,6S-(N'-butyliminomethylidene)-6-thio-1-deoxygalactonojirimycin	DM7RHOC	GM1 gangliosidosis	5C56.00	Preclinical	[4]
N-Octyl-4-epi-beta-valienamine	DMTQ2UD	GM1 gangliosidosis	5C56.00	Preclinical	[5]

References

• [1] Clinical pipeline report, company report or official report of Axovant Gene Therapies
• [2] ClinicalTrials.gov (NCT04273269) An Open-Label Adaptive-Design Study of Intracisternal Adenoassociated Viral Vector Serotype rh.10 Carrying the Human beta-Galactosidase cDNA for Treatment of GM1 Gangliosidosis. U.S.National Institutes of Health.
• [3] Clinical pipeline report, company report or official report of Passage Bio
• [4] A bicyclic 1-deoxygalactonojirimycin derivative as a novel pharmacological chaperone for GM1 gangliosidosis. Mol Ther. 2013 Mar;21(3):526-32.
• [5] Chemical modification of the beta-glucocerebrosidase inhibitor N-octyl-beta-valienamine: synthesis and biological evaluation of 4-epimeric and 4-O-(beta-D-galactopyranosyl) derivatives. Bioorg Med Chem. 2002 Jun;10(6):1967-72.