Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTNIUKC)

DTT Name	TMPRSS6 messenger RNA (TMPRSS6 mRNA) DTT Info
Gene Name	TMPRSS6

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Clinical Trial Drug(s)

Preclinical Drug(s)

Download the Complete Related Drug List

3 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IONIS-TMPRSS6-LRx	DM7VJE1	Beta thalassemia	3A50.2	Phase 2	[1]
Sapablursen	DM95T5Z	Polycythemia vera	2A20.4	Phase 2	[2]
SLN124	DMIAOU6	Beta thalassemia	3A50.2	Phase 1	[3]
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1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ALN-TMP	DMW7XEU	Beta thalassemia	3A50.2	Preclinical	[4]
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Molecule Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

References

1	Clinical pipeline report, company report or official report of Ionis Pharmaceuticals.
2	Clinical pipeline report, company report or official report of Ionis
3	SLN124, a GalNAc-siRNA Conjugate Targeting TMPRSS6, Efficiently Prevents Iron Overload in Hereditary Haemochromatosis Type 1. Hemasphere. 2019 Oct 1;3(6):e301.
4	Targeting iron metabolism in drug discovery and delivery. Nat Rev Drug Discov. 2017 Jun;16(6):400-423.