General Information of DTT (ID: TTOMNR9)

DTT Name Somatostatin receptor (SSTR) DTT Info
Gene Name SSTR

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Discontinued Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
9 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
177-Lu-oxodotreotide DMMZS2T Neuroendocrine cancer 2B72.1 Phase 3 [1]
177Lu-DOTA-octreotate DMP5L8S Melanoma 2C30 Phase 3 [2]
177Lu-DOTATATE DMT8GVU Hepatitis C virus infection 1E51.1 Phase 2 [2]
Edotreotide DMQ08AJ Acromegaly 5A60.0 Phase 2 [3]
FK-962 DMV0MZ3 Alzheimer disease 8A20 Phase 2 [4]
Somatoprim DMTVS3A Acromegaly 5A60.0 Phase 2 [5]
177Lu-labelled DOTA-JR11 DMVZ9XL Neuroendocrine cancer 2B72.1 Phase 1/2 [6]
212Pb-labelled DOTAMTATE DMN9MPX Neuroendocrine cancer 2B72.1 Phase 1 [7]
AlphaMedix DMBVM1Q Neuroendocrine cancer 2B72.1 Phase 1 [8]
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⏷ Show the Full List of 9 Clinical Trial Drug(s)
3 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIM-23268 DMIZ59O Acromegaly 5A60.0 Discontinued in Phase 2 [3]
FK-960 DMPD8O2 Cognitive impairment 6D71 Discontinued in Phase 2 [4]
SEGLITIDE DMXZVPH Pain MG30-MG3Z Discontinued in Phase 2 [9]
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1 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ilatreotide DMPIV1G Duodenal ulcer DA63 Investigative [10]
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Molecule Interaction Atlas

References

1 Lutetium-labelled peptides for therapy of neuroendocrine tumours. Eur J Nucl Med Mol Imaging. 2012 Feb;39 Suppl 1(Suppl 1):S103-12.
2 Peptide receptor radionuclide therapy with 177Lu-DOTATATE for patients with somatostatin receptor-expressing neuroendocrine tumors: the first US phase 2 experience. Pancreas. 2014 May;43(4):518-25.
3 Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
4 FK960, a novel potential anti-dementia drug, enhances high K(+)-evoked release of somatostatin from rat hippocampal slices. Brain Res. 2001 Feb 16;892(1):111-7.
5 DG3173 (somatoprim), a unique somatostatin receptor subtypes 2-, 4- and 5-selective analogue, effectively reduces GH secretion in human GH-secreting pituitary adenomas even in Octreotide non-responsive tumours.Eur J Endocrinol.2012 Feb;166(2):223-34.
6 Multimodal Imaging of 2-Cycle PRRT with 177 Lu-DOTA-JR11 and 177 Lu-DOTATOC in an Orthotopic Neuroendocrine Xenograft Tumor Mouse Model. J Nucl Med. 2021 Mar;62(3):393-398.
7 Radiopharmaceutical therapy in cancer: clinical advances and challenges. Nat Rev Drug Discov. 2020 Sep;19(9):589-608.
8 Clinical pipeline report, company report or official report of Orano Med.
9 Antagonist effects of seglitide (MK 678) at somatostatin receptors in guinea-pig isolated right atria.. Br J Pharmacol. 1993 August; 109(4): 898-899.
10 Inhibitory effect of intraduodenal administration of somatostatin analogue SDZ CO 611 on rat pancreatic exocrine secretion. Pancreas. 1993 Jul;8(4):471-5.