Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTPCG5T)

• DTT Name: Hepcidin (HAMP) DTT Info
• Gene Name: HAMP

Molecule-Related Drug & Molecule List

5 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LJPC-401	DMVM13R	Beta thalassemia	3A50.2	Phase 2	[1]
NOX-H94	DM5HPZU	Anemia	3A00-3A9Z	Phase 2	[2]
PTG-300	DMOYS8A	Hemochromatosis	5C64.1Y	Phase 2	[3]
Hepcidin mab	DMBFYSR	Anemia	3A00-3A9Z	Phase 1	[4]
LY2787106	DM9NYHT	Anemia	3A00-3A9Z	Phase 1	[5]

1 Preclinical Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
12B9m	DM5IUN8	Anaemia	3A90	Preclinical	[6]

References

• [1] ClinicalTrials.gov (NCT03395704) A Study of LJPC-401 for the Treatment of Iron Overload in Adult Patients With Hereditary Hemochromatosis. U.S. National Institutes of Health.
• [2] The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys. Blood. 2013 Mar 21;121(12):2311-5.
• [3] Clinical pipeline report, company report or official report of Protagonist Therapeutics.
• [4] The pathophysiology and pharmacology of hepcidin. Trends Pharmacol Sci. 2014 March; 35(3): 155-161.
• [5] A first-in-human phase 1 study of a hepcidin monoclonal antibody, LY2787106, in cancer-associated anemia. J Hematol Oncol. 2017 Mar 21;10(1):73.
• [6] Pharmacokinetics of anti-hepcidin monoclonal antibody Ab 12B9m and hepcidin in cynomolgus monkeys. AAPS J. 2010 Dec;12(4):646-57.