Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTR5TV4)

• DTT Name: ERBB2 messenger RNA (HER2 mRNA) DTT Info
• Gene Name: ERBB2

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HKI-272	DM6QOVN	Breast cancer	2C60-2C65	Phase 3	[1]
BMS-690514	DMX302C	Chronic pain	MG30	Phase 2	[2]

26 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(1-Benzyl-1H-indol-5-yl)-quinazolin-4-yl-amine	DM0SCW9	Discovery agent	N.A.	Investigative	[3]
3,4-di-(4-methoxyphenyl)-1H-pyrrole-2,5-dione	DMDO175	Discovery agent	N.A.	Investigative	[4]
3,4-diphenyl-1H-pyrrole-2,5-dione	DMPK6YT	Discovery agent	N.A.	Investigative	[4]
3-(4-methoxyphenyl)-4-phenyl-1H-pyrrole-2,5-dione	DMGC7RY	Discovery agent	N.A.	Investigative	[4]
3-(indole-3-yl)-4-phenyl-1H-pyrrole-2,5-dione	DM3EV9N	Discovery agent	N.A.	Investigative	[4]
4-(3-phenoxylphenyl)-5-cyano-2H-1,2,3-triazole	DMSXG23	Discovery agent	N.A.	Investigative	[5]
4-(4-bromophenyl)-5-cyano-2H-1,2,3-triazole	DMFEBCO	Discovery agent	N.A.	Investigative	[5]
4-(4-chlorophenyl)-5-cyano-2H-1,2,3-triazole	DMVN7GC	Discovery agent	N.A.	Investigative	[5]
4-(4-isopropylphenyl)-5-cyano-2H-1,2,3-triazole	DMRGM21	Discovery agent	N.A.	Investigative	[5]
4-(Bis(2-chloroethyl)amino)-N-p-tolylbenzamide	DMNE5H7	Discovery agent	N.A.	Investigative	[6]
4557W	DMLE0I7	Discovery agent	N.A.	Investigative	[3]
AG-213	DMT3ML6	Discovery agent	N.A.	Investigative	[7]
BMS-536924	DMXJB4N	Discovery agent	N.A.	Investigative	[8]
CL-387785	DMLKFZC	Discovery agent	N.A.	Investigative	[9]
Geldanamycin-estradiol hybrid	DMUSJ96	Discovery agent	N.A.	Investigative	[10]
HDS-029	DMLRUVA	Discovery agent	N.A.	Investigative	[9]
ISIS 12882	DMAXB8T	Discovery agent	N.A.	Investigative	[11]
ISIS 12883	DMND0JL	Discovery agent	N.A.	Investigative	[11]
ISIS 12884	DMS15A3	Discovery agent	N.A.	Investigative	[11]
ISIS 9002	DMLIRKY	Discovery agent	N.A.	Investigative	[11]
ISIS 9003	DMBL2CG	Discovery agent	N.A.	Investigative	[11]
ISIS 9005	DM3PVGC	Discovery agent	N.A.	Investigative	[11]
N-(4-m-Tolylamino-quinazolin-6-yl)-acrylamide	DMEBGF1	Discovery agent	N.A.	Investigative	[12]
PD-168393	DMN8M5P	Discovery agent	N.A.	Investigative	[12]
PMID24915291C38	DMBXT9J	Discovery agent	N.A.	Investigative	[13]
PNT-500	DMIEKVB	Solid tumour/cancer	2A00-2F9Z	Investigative	[14]

References

• [1] Identification of genotype-correlated sensitivity to selective kinase inhibitors by using high-throughput tumor cell line profiling. Proc Natl Acad Sci U S A. 2007 Dec 11;104(50):19936-41.
• [2] Preclinical pharmacokinetics and in vitro metabolism of BMS-690514, a potent inhibitor of EGFR and VEGFR2. J Pharm Sci. 2010 Aug;99(8):3579-93.
• [3] Indazolylamino quinazolines and pyridopyrimidines as inhibitors of the EGFr and C-erbB-2. Bioorg Med Chem Lett. 2001 Jun 4;11(11):1401-5.
• [4] Design, synthesis, and biological evaluation of 3,4-diarylmaleimides as angiogenesis inhibitors. J Med Chem. 2006 Feb 23;49(4):1271-81.
• [5] Synthesis and biological evaluation of 4-aryl-5-cyano-2H-1,2,3-triazoles as inhibitor of HER2 tyrosine kinase. Bioorg Med Chem. 2007 Feb 1;15(3):1533-8.
• [6] Synthesis, biological evaluation and molecular docking studies of amide-coupled benzoic nitrogen mustard derivatives as potential antitumor agents. Bioorg Med Chem. 2010 Jan 15;18(2):880-6.
• [7] Syntheses of 4-(indole-3-yl)quinazolines: a new class of epidermal growth factor receptor tyrosine kinase inhibitors. Eur J Med Chem. 2008 Jul;43(7):1478-88.
• [8] Discovery of a (1H-benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) inhibitor of insulin-like growth factor I receptor kinase with in vivo antitum... J Med Chem. 2005 Sep 8;48(18):5639-43.
• [9] Tyrosine kinase inhibitors. 19. 6-Alkynamides of 4-anilinoquinazolines and 4-anilinopyrido[3,4-d]pyrimidines as irreversible inhibitors of the erbB... J Med Chem. 2006 Feb 23;49(4):1475-85.
• [10] Synthesis and evaluation of geldanamycin-estradiol hybrids. Bioorg Med Chem Lett. 1999 May 3;9(9):1233-8.
• [11] US patent application no. 5,968,748, Antisense oligonucleotide modulation of human HER-2 expression.
• [12] Tyrosine kinase inhibitors. 15. 4-(Phenylamino)quinazoline and 4-(phenylamino)pyrido[d]pyrimidine acrylamides as irreversible inhibitors of the ATP... J Med Chem. 1999 May 20;42(10):1803-15.
• [13] Discovery of a series of 2,5-diaminopyrimidine covalent irreversible inhibitors of Bruton's tyrosine kinase with in vivo antitumor activity. J Med Chem. 2014 Jun 26;57(12):5112-28.
• [14] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2019).