Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTRE6AX)

• DTT Name: Bcl-x messenger RNA (BCL2L1 mRNA) DTT Info
• Gene Name: BCL2L1

Molecule-Related Drug & Molecule List

1 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PURPUROGALLIN	DM63O4F	N. A.	N. A.	Terminated	[1]

13 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
4,5-dibenzylbenzene-1,2-diol	DMHURXY	Discovery agent	N.A.	Investigative	[2]
ISIS 11219	DMW3145	Discovery agent	N.A.	Investigative	[3]
ISIS 11220	DMNJS0K	Discovery agent	N.A.	Investigative	[3]
ISIS 11221	DMDUIG3	Discovery agent	N.A.	Investigative	[3]
ISIS 11223	DM7LPI4	Discovery agent	N.A.	Investigative	[3]
ISIS 11224	DMMGA6K	Discovery agent	N.A.	Investigative	[3]
ISIS 15998	DMAQ9EB	Discovery agent	N.A.	Investigative	[3]
ISIS 15999	DMMEP6J	Discovery agent	N.A.	Investigative	[3]
ISIS 16005	DMDORHA	Discovery agent	N.A.	Investigative	[3]
ISIS 16009	DMBRKFC	Discovery agent	N.A.	Investigative	[3]
ISIS 16010	DMZID0W	Discovery agent	N.A.	Investigative	[3]
QEDIIRNIARHLAQVGDSMDR	DMJ38YV	Discovery agent	N.A.	Investigative	[4]
TW-37	DMDE8YS	Discovery agent	N.A.	Investigative	[5]

References

• [1] Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins. J Med Chem. 2003 Sep 25;46(20):4259-64.
• [2] Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. J Med Chem. 2010 May 27;53(10):3899-906.
• [3] US patent application no. 7,148,204, Antisense modulation of bcl-x expression.
• [4] Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. J Med Chem. 2006 Oct 19;49(21):6139-42.
• [5] Fragment-based deconstruction of Bcl-xL inhibitors. J Med Chem. 2010 Mar 25;53(6):2577-88.