Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTSIUJ9)

• DTT Name: Interferon-alpha 2 (IFNA2) DTT Info
• Gene Name: IFNA2

Molecule-Related Drug & Molecule List

3 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Interferon Alfa-2b	DMWCQP4	Melanoma	2C30	Approved	[1]
Peginterferon alfa-2a	DMJI3BA	Chronic hepatitis B virus infection		Approved	[1]
Peginterferon alfa-2b	DMAP58Y	Hepatitis C virus infection	1E51.1	Approved	[1]

9 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Albinterferon alfa-2b	DMK0QW6	Hepatitis C virus infection	1E51.1	Phase 3	[2]
Hebergel	DMQTLVB	Virus infection	1A24-1D9Z	Phase 3	[3]
Interferon alpha 2a	DMOTH6V	Hepatitis C virus infection	1E51.1	Phase 3	[4]
P-1101	DM7WYXJ	Essential thrombocythemia	3B63.1Z	Phase 3	[5]
Instiladrin	DMNKAFQ	Bladder cancer	2C94	Phase 2	[6]
Interferon alpha-2b	DMVACTU	Hepatitis C virus infection	1E51.1	Phase 2	[7]
Novaferon	DMEHOI1	Colorectal cancer	2B91.Z	Phase 2	[8]
CIGB-128	DMB2MKU	Basal cell carcinoma	2C32	Phase 1	[9]
SCH-721015	DMDP6UF	Mesothelioma	2C51.2	Phase 1	[10]

2 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
HAp-IFN	DM9K6H5	Hepatitis C virus infection	1E51.1	Investigative	[11]
subalin	DMKH9IE	Discovery agent	N.A.	Investigative	[12]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [2] Albinterferon alfa-2b, a novel fusion protein of human albumin and human interferon alfa-2b, for chronic hepatitis C. Curr Med Res Opin. 2009 Apr;25(4):991-1002.
• [3] Evaluation of recombinant human interferon alpha-2b structure and stability by in-gel tryptic digestion, H/D exchange and mass spectrometry. J Pharm Biomed Anal. 2006 Feb 24;40(3):781-7.
• [4] Hairy cell leukemia associated with large granular lymphocyte leukemia: immunologic and genomic study, effect of interferon treatment. Blood. 1988 Aug;72(2):655-60.
• [5] Effects of PEG-interferon-alpha-2A on Schistosoma mansoni infection in mice. J Parasitol. 2010 Aug;96(4):703-8.
• [6] ClinicalTrials.gov (NCT01687244) Intravesical Administration of rAd-IFN/Syn3 in Patients With BCG-Refractory or Relapsed Bladder Cancer. U.S. National Institutes of Health.
• [7] Clinical pipeline report, company report or official report of Avarx.
• [8] Novaferon, a novel recombinant protein produced by DNA-shuffling of IFN-alpha, shows antitumor effect in vitro and in vivo. Cancer Cell Int. 2014; 14: 8.
• [9] Pharmacokinetic and pharmacodynamic characterization of a new formulation containing synergistic proportions of interferons alpha-2b and gamma (HeberPAG) in patients with mycosis fungoides: an open-label trial.BMC Pharmacol Toxicol.2012 Dec 28;13:20.
• [10] Toxicity and exposure of an adenovirus containing human interferon alpha-2b following intracystic administration in cynomolgus monkeys. Gene Ther. 2012 Jul;19(7):742-51.
• [11] CN patent application no. 1921880, Protein drug sustained-release microparticle preparation for injection and process for producing the same.
• [12] [Adjuvant properties of subalin, a recombinant interferon-producing probiotic].Zh Mikrobiol Epidemiol Immunobiol.2001 Nov-Dec;(6):77-82.