Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTT02K8)

• DTT Name: Steroid 5-alpha-reductase 2 (SRD5A2) DTT Info
• Gene Name: SRD5A2

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Finasteride	DMWV3TZ	Baldness, male pattern		Approved	[1]

15 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(3-fluoro-4-(4-phenoxybenzoyl)phenyl)acetic acid	DMPHM23	Discovery agent	N.A.	Investigative	[2]
(3-methyl-4-(4-phenoxybenzoyl)phenyl)acetic acid	DMX5CY3	Discovery agent	N.A.	Investigative	[2]
(E)-3-(4-(4-phenoxybenzoyl)phenyl)acrylic acid	DMOWGT3	Discovery agent	N.A.	Investigative	[2]
2,3,5,6-Tetrafluoro-4-pentafluorophenylazo-phenol	DMRVYKQ	Discovery agent	N.A.	Investigative	[3]
3-[4-(4-phenoxybenzoyl)phenyl]propanoic acid	DM75F1Q	Discovery agent	N.A.	Investigative	[2]
4,4'-dihydroxyoctafluoroazobenzene	DM1ONBT	Discovery agent	N.A.	Investigative	[3]
4-(4-phenoxybenzoyl)benzoic acid	DMOHB6U	Discovery agent	N.A.	Investigative	[2]
4-(4-phenoxybenzoyl)phenylacetic acid	DMQ0JWZ	Discovery agent	N.A.	Investigative	[2]
4-[3-(benzyloxy)benzoyl]benzoic acid	DMZU23D	Discovery agent	N.A.	Investigative	[2]
4-[4-(benzhydryloxy)benzoyl]benzoic acid	DM8MVE9	Discovery agent	N.A.	Investigative	[2]
4-[4-(benzoylamino)benzoyl]benzoic acid	DM9VPFL	Discovery agent	N.A.	Investigative	[2]
4-[4-(benzylamino)benzoyl]benzoic acid	DMQC5EH	Discovery agent	N.A.	Investigative	[2]
4-[4-benzyloxy)benzoyl]benzoic acid	DMQ9IN4	Discovery agent	N.A.	Investigative	[2]
GP515	DMRUIX3	Discovery agent	N.A.	Investigative	[4]
{4-[4-(4-bromophenoxy)benzoyl]phenyl}acetic acid	DMX53OY	Discovery agent	N.A.	Investigative	[2]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] Novel 5alpha-reductase inhibitors: synthesis, structure-activity studies, and pharmacokinetic profile of phenoxybenzoylphenyl acetic acids. J Med Chem. 2006 Jan 26;49(2):748-59.
• [3] Hydroxyperfluoroazobenzenes: novel inhibitors of enzymes of androgen biosynthesis. J Med Chem. 1990 Sep;33(9):2452-5.
• [4] 19-nor-10-azasteroids: a novel class of inhibitors for human steroid 5alpha-reductases 1 and 2. J Med Chem. 1997 Mar 28;40(7):1112-29.