Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTT6LFV)

• DTT Name: Histone deacetylase 8 (HDAC8) DTT Info
• UniProt ID: HDAC8_HUMAN
• Gene Name: HDAC8

Molecule-Related Drug & Molecule List

1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NBM-BMX	DM5OWXA	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]

14 Patented Agent(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID29671355-Compound-13	DMALXYR	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-21	DMPJN0M	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-23	DMUBOEX	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-25	DMPV0KZ	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-31	DM3H78D	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-36	DMQJ3TC	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-37	DMJ1O5R	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-43	DMVPMWJ	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-44	DM80A3V	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-56	DM0VBMI	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-61	DMXH1G3	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-62	DMWRS34	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-67	DM1RPL4	N. A.	N. A.	Patented	[2]
PMID29671355-Compound-68b	DMLGBR6	N. A.	N. A.	Patented	[2]

71 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(E)-8-Biphenyl-4-yl-1-oxazol-2-yl-oct-7-en-1-one	DM5LSY9	Discovery agent	N.A.	Investigative	[3]
2-(methylsulfonylthio)ethyl 2-propylpentanoate	DMM52D3	Discovery agent	N.A.	Investigative	[4]
4-Benzoylamino-N-hydroxy-benzamide	DMYBPFS	Discovery agent	N.A.	Investigative	[5]
4-Butyrylamino-N-hydroxy-benzamide	DMRY6B4	Discovery agent	N.A.	Investigative	[6]
4-Chloro-N-(5-hydroxycarbamoyl-pentyl)-benzamide	DM5AVG3	Discovery agent	N.A.	Investigative	[7]
4-Dimethylamino-N-(6-mercapto-hexyl)-benzamide	DM0M8G5	Discovery agent	N.A.	Investigative	[8]
4-Hydroxy-N-(5-hydroxycarbamoyl-pentyl)-benzamide	DMULOHZ	Discovery agent	N.A.	Investigative	[7]
4-Phenylbutyrohydroxamic acid	DMCZKN7	Discovery agent	N.A.	Investigative	[9]
5-(4-Chloro-phenyl)-pentanoic acid hydroxyamide	DM6CRVS	Discovery agent	N.A.	Investigative	[10]
5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione	DM7KQXL	Discovery agent	N.A.	Investigative	[4]
5-Mercapto-pentanoic acid phenylamide	DMET3OJ	Discovery agent	N.A.	Investigative	[8]
6-(2-Bromo-acetylamino)-hexanoic acid phenylamide	DM9LKXD	Discovery agent	N.A.	Investigative	[8]
6-(2-mercaptoacetamido)-N-phenylhexanamide	DM9P4LB	Discovery agent	N.A.	Investigative	[11]
6-benzenesulfinylhexanoic acid hydroxamide	DM2I95Z	Discovery agent	N.A.	Investigative	[12]
6-benzenesulfonylhexanoic acid hydroxamide	DMY9IK8	Discovery agent	N.A.	Investigative	[12]
6-Mercapto-hexanoic acid phenylamide	DMD2FW9	Discovery agent	N.A.	Investigative	[8]
6-Phenoxy-hexane-1-thiol	DMVYIN2	Discovery agent	N.A.	Investigative	[8]
6-phenylsulfanylhexanoic acid hydroxamide	DM3OLM6	Discovery agent	N.A.	Investigative	[12]
7-(Biphenyl-3-yloxy)-1-oxazol-2-yl-heptan-1-one	DMLCGSY	Discovery agent	N.A.	Investigative	[3]
7-(Biphenyl-4-yloxy)-1,1,1-trifluoro-heptan-2-one	DM28GZ7	Discovery agent	N.A.	Investigative	[13]
7-(Biphenyl-4-yloxy)-1-oxazol-2-yl-heptan-1-one	DMY027P	Discovery agent	N.A.	Investigative	[3]
7-(Naphthalen-2-yloxy)-1-oxazol-2-yl-heptan-1-one	DM4VQN8	Discovery agent	N.A.	Investigative	[3]
7-Mercapto-heptanoic acid benzothiazol-2-ylamide	DMPYTHV	Discovery agent	N.A.	Investigative	[8]
7-Mercapto-heptanoic acid biphenyl-3-ylamide	DMEQKPO	Discovery agent	N.A.	Investigative	[8]
7-Mercapto-heptanoic acid biphenyl-4-ylamide	DMJMOUK	Discovery agent	N.A.	Investigative	[8]
7-Mercapto-heptanoic acid phenylamide	DM4912P	Discovery agent	N.A.	Investigative	[8]
7-Mercapto-heptanoic acid pyridin-3-ylamide	DMQ9PLA	Discovery agent	N.A.	Investigative	[8]
7-Mercapto-heptanoic acid quinolin-3-ylamide	DMTAGJ1	Discovery agent	N.A.	Investigative	[8]
8-(Biphenyl-4-yloxy)-1,1,1-trifluoro-octan-2-one	DM23XGW	Discovery agent	N.A.	Investigative	[3]
8-Mercapto-octanoic acid phenylamide	DMD3FWU	Discovery agent	N.A.	Investigative	[8]
8-Oxo-8-phenyl-octanoic acid	DMXDQ25	Discovery agent	N.A.	Investigative	[7]
9,9,9-Trifluoro-8-oxo-nonanoic acid phenylamide	DMVBCID	Discovery agent	N.A.	Investigative	[13]
9-(Biphenyl-4-yloxy)-1,1,1-trifluoro-nonan-2-one	DMIY3D6	Discovery agent	N.A.	Investigative	[13]
9-mercapto-8-oxo-N-phenylnonanamide	DMW905K	Discovery agent	N.A.	Investigative	[11]
Azithromycin-N-benzyltriazolylhexahydroxamic Acid	DM7KD5Y	Discovery agent	N.A.	Investigative	[14]
Azithromycin-N-benzyltriazolylnonahydroxamic Acid	DMW0HXO	Discovery agent	N.A.	Investigative	[14]
Azithromycin-N-benzyltriazolyloctahydroxamic Acid	DMAJ4LI	Discovery agent	N.A.	Investigative	[14]
Azithromycinarylalkylhydroxamic Acid	DM8ZQG3	Discovery agent	N.A.	Investigative	[14]
Cyclostellettamine derivative	DMFTDPQ	Discovery agent	N.A.	Investigative	[15]
Desclasinose Azithromycinarylalkyl Hydroxamate	DMAB9KG	Discovery agent	N.A.	Investigative	[14]
droxinostat	DM5IA9W	Discovery agent	N.A.	Investigative	[16]
N-(2-Mercapto-ethyl)-N'-phenyl-oxalamide	DM0GOPV	Discovery agent	N.A.	Investigative	[17]
N-(2-Mercapto-ethyl)-N'-phenyl-succinamide	DMJLFOQ	Discovery agent	N.A.	Investigative	[17]
N-(5-Hydroxycarbamoyl-pentyl)-4-nitro-benzamide	DMSUW7M	Discovery agent	N.A.	Investigative	[7]
N-(6-Hydroxycarbamoyl-hexyl)-benzamide	DMIZVMT	Discovery agent	N.A.	Investigative	[7]
N-(6-Mercapto-hexyl)-benzamide	DM01Y37	Discovery agent	N.A.	Investigative	[8]
N-hydroxy-1-naphthamide	DMZ2T59	Discovery agent	N.A.	Investigative	[18]
N-hydroxy-3-(naphthalen-1-yl)acrylamide	DMY6Z0U	Discovery agent	N.A.	Investigative	[18]
N-hydroxy-3-phenoxybenzamide	DMTZ8RQ	Discovery agent	N.A.	Investigative	[18]
N-Hydroxy-4-((R)-2-phenyl-butyrylamino)-benzamide	DMCN91A	Discovery agent	N.A.	Investigative	[5]
N-Hydroxy-4-((S)-2-phenyl-butyrylamino)-benzamide	DMVK2Y3	Discovery agent	N.A.	Investigative	[5]
N-Hydroxy-4-(2-phenyl-butyrylamino)-benzamide	DMHEQ41	Discovery agent	N.A.	Investigative	[5]
N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide	DMUOCQB	Discovery agent	N.A.	Investigative	[5]
N-Hydroxy-4-(4-phenyl-butyrylamino)-benzamide	DMVEOBY	Discovery agent	N.A.	Investigative	[5]
N-Hydroxy-4-(5-phenyl-pentanoylamino)-benzamide	DMISRMT	Discovery agent	N.A.	Investigative	[5]
N-hydroxy-4-(naphthalen-1-yl)benzamide	DMSHQE3	Discovery agent	N.A.	Investigative	[18]
N-Hydroxy-4-(pentanoylamino-methyl)-benzamide	DMGTNQY	Discovery agent	N.A.	Investigative	[6]
N-Hydroxy-4-(phenylacetylamino-methyl)-benzamide	DMDUOH4	Discovery agent	N.A.	Investigative	[6]
N-Hydroxy-4-phenylacetylamino-benzamide	DMCRU17	Discovery agent	N.A.	Investigative	[5]
NILTUBACIN	DM0QJSO	Discovery agent	N.A.	Investigative	[9]
NMB-T-BMX-OS01	DM5Q9FG	Solid tumour/cancer	2A00-2F9Z	Investigative	[19]
Octanedioic acid bis-hydroxyamide	DMJNQ9K	Discovery agent	N.A.	Investigative	[9]
Octanedioic acid hydroxyamide pyridin-2-ylamide	DMHNWS1	Discovery agent	N.A.	Investigative	[7]
Octanedioic acid hydroxyamide pyridin-4-ylamide	DM945RK	Discovery agent	N.A.	Investigative	[7]
PCI-34051	DMIMPDL	Solid tumour/cancer	2A00-2F9Z	Investigative	[19]
PSAMMAPLIN A	DM6T0IQ	Discovery agent	N.A.	Investigative	[13]
S-2,9-dioxo-9-(phenylamino)nonyl ethanethioate	DMTH15E	Discovery agent	N.A.	Investigative	[11]
ST-2986	DMNERM6	Discovery agent	N.A.	Investigative	[20]
ST-2987	DMWXTM8	Solid tumour/cancer	2A00-2F9Z	Investigative	[20]
ST-3050	DM19K2D	Discovery agent	N.A.	Investigative	[20]
Thioacetic acid S-(6-phenylcarbamoyl-hexyl) ester	DMBOKSF	Discovery agent	N.A.	Investigative	[8]

References

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• [4] New sulfurated derivatives of valproic acid with enhanced histone deacetylase inhibitory activity. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1893-7.
• [5] Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. J Med Chem. 2005 Aug 25;48(17):5530-5.
• [6] Zn2+-chelating motif-tethered short-chain fatty acids as a novel class of histone deacetylase inhibitors. J Med Chem. 2004 Jan 15;47(2):467-74.
• [7] Inhibitors of human histone deacetylase: synthesis and enzyme and cellular activity of straight chain hydroxamates. J Med Chem. 2002 Feb 14;45(4):753-7.
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• [11] Histone deacetylase inhibitors: from bench to clinic. J Med Chem. 2008 Mar 27;51(6):1505-29.
• [12] Aromatic sulfide inhibitors of histone deacetylase based on arylsulfinyl-2,4-hexadienoic acid hydroxyamides. J Med Chem. 2006 Jan 26;49(2):800-5.
• [13] Histone deacetylase inhibitors. J Med Chem. 2003 Nov 20;46(24):5097-116.
• [14] Non-peptide macrocyclic histone deacetylase inhibitors. J Med Chem. 2009 Jan 22;52(2):456-68.
• [15] Three new cyclostellettamines, which inhibit histone deacetylase, from a marine sponge of the genus Xestospongia. Bioorg Med Chem Lett. 2004 May 17;14(10):2617-20.
• [16] Selective inhibition of histone deacetylases sensitizes malignant cells to death receptor ligands. Mol Cancer Ther. 2010 Jan;9(1):246-56.
• [17] Mercaptoamide-based non-hydroxamic acid type histone deacetylase inhibitors. Bioorg Med Chem Lett. 2005 Apr 15;15(8):1969-72.
• [18] Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15;17(10):2874-8.
• [19] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2619).
• [20] N-Hydroxy-(4-oxime)-cinnamide: a versatile scaffold for the synthesis of novel histone deacetylase [correction of deacetilase] (HDAC) inhibitors. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2346-9.