Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTV23LH)

• DTT Name: Delta-like protein 4 (DLL4) DTT Info
• Gene Name: DLL4

Molecule-Related Drug & Molecule List

6 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dilpacimab	DMCATH2	Solid tumour/cancer	2A00-2F9Z	Phase 2	[1]
ABT-165	DMQ3O1U	Solid tumour/cancer	2A00-2F9Z	Phase 1	[2]
Navicixizumab	DMZ2G69	Colorectal cancer	2B91.Z	Phase 1	[3]
NOV1501	DME2QUZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
OMP-21M18	DMX1D0S	Solid tumour/cancer	2A00-2F9Z	Phase 1	[5]
REGN-421	DMWJ0IH	Solid tumour/cancer	2A00-2F9Z	Phase 1	[6]

References

• [1] Apoptogenic activity of 2alpha,3alpha-dihydroxyurs-12-ene-28-oic acid from Prunella vulgaris var. lilacina is mediated via mitochondria-dependent activation of caspase cascade regulated by Bcl-2 in human acute leukemia Jurkat T cells. J Ethnopharmacol. 2011 Jun 1;135(3):626-35.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Synergistic antitumor activity of a DLL4/VEGF bispecific therapeutic antibody in combination with irinotecan in gastric cancer. BMB Rep. 2020 Nov;53(10):533-538.
• [5] National Cancer Institute Drug Dictionary (drug id 614677).
• [6] J Clin Oncol 31, 2013 (suppl; abstr 2502).