Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTVIAT9)

• DTT Name: Phosphodiesterase 4B (PDE4B) DTT Info
• Gene Name: PDE4B

Molecule-Related Drug & Molecule List

20 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BI 1015550	DM6DO2P	Idiopathic pulmonary fibrosis	CB03.4	Phase 3	[1]
DENBUFYLLINE	DM2R15Q	Cognitive impairment	6D71	Phase 3	[2]
SOTB07	DMIG4OX	Asthma	CA23	Phase 3	[3]
AN-2898	DMDK7CL	Atopic dermatitis	EA80	Phase 2	[4]
AWD-12-281	DMVADGZ	Rhinitis	FA20	Phase 2	[5]
CC-1088	DMQ874W	Crohn disease	DD70	Phase 2	[6]
GPD-1116	DMOQ7YI	Asthma	CA23	Phase 2	[7]
HT-0712	DM2WP8F	Cognitive impairment	6D71	Phase 2	[3]
LIRIMILAST	DMD4KAU	Chronic obstructive pulmonary disease	CA22	Phase 2	[8]
MK-0873	DM0568C	Psoriasis vulgaris	EA90	Phase 2	[9]
Oglemilast	DMVC90W	Asthma	CA23	Phase 2	[10]
OX-914	DM5Q9RY	Asthma	CA23	Phase 2	[11]
Piclamilast	DMYL7VR	Rheumatoid arthritis	FA20	Phase 2	[12]
Revamilast	DM1FS2W	Asthma	CA23	Phase 2	[13]
TA-7906	DMZTAJL	Atopic dermatitis	EA80	Phase 2	[14]
TOFIMILAST	DMLCUAS	Chronic obstructive pulmonary disease	CA22	Phase 2	[8]
AVE-8112	DMZNTHJ	Parkinson disease	8A00.0	Phase 1	[15]
GSK-356278	DMIEAMU	Huntington disease	8A01.10	Phase 1	[16]
MEM-1414	DMA1KQV	Mood disorder	6A60-6E23	Phase 1	[17]
Ronomilast	DM82KWY	Chronic obstructive pulmonary disease	CA22	Phase 1	[18]

15 Discontinued Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CDP840	DMUPJW4	Chronic obstructive pulmonary disease	CA22	Discontinued in Phase 2	[19]
CI-1018	DM03XVA	Asthma	CA23	Discontinued in Phase 2	[20]
Daxalipram	DMXO9BQ	Multiple sclerosis	8A40	Discontinued in Phase 2	[21]
Filaminast	DMGD5QN	Chronic obstructive pulmonary disease	CA22	Discontinued in Phase 2	[22]
KW-4490	DMSWDKX	Asthma	CA23	Discontinued in Phase 2	[23]
LAS-37779	DM9J6BX	Psoriasis vulgaris	EA90	Discontinued in Phase 2	[24]
V-11294A	DMEV1H5	Asthma	CA23	Discontinued in Phase 2	[25]
D-4418	DMUPEJK	Cutaneous T-cell lymphoma	2B01	Discontinued in Phase 1	[26]
SCH-351591	DMK40VO	Chronic obstructive pulmonary disease	CA22	Discontinued in Phase 1	[27]
YM-976	DMCDK6S	Asthma	CA23	Discontinued in Phase 1	[8]
D-22888	DM7FTCV	Allergy	4A80-4A85	Terminated	[28]
GW-3600	DMSZH0I	Asthma	CA23	Terminated	[29]
NIK-616	DM4U7XB	Chronic obstructive pulmonary disease	CA22	Terminated	[30]
TJN-598	DMKSPYI	Glomerulonephritis	5D00.Y	Terminated	[31]
Torbafylline	DMRBGI6	Peripheral vascular disease	BD4Z	Terminated	[32]

32 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(R)-Rolipram	DM95Z4Q	Discovery agent	N.A.	Investigative	[33]
(S)-Rolipram	DM1SJZ3	Discovery agent	N.A.	Investigative	[33]
3-(2-Bromophenyl)-2-thioxo-(1H )-quinazolin-4-one	DMH6I4E	Discovery agent	N.A.	Investigative	[34]
8-(3-Nitro-phenyl)-6-phenyl-[1,7]naphthyridine	DMP6Z3R	Discovery agent	N.A.	Investigative	[35]
8-Bromo-Adenosine-5'-Monophosphate	DM4CV1E	Discovery agent	N.A.	Investigative	[36]
AL-59640	DMPHTX0	Xerophthalmia	5B55.Y	Investigative	[3]
ASP-3258	DMZ9GQR	Respiratory tract inflammation	CA07	Investigative	[3]
Benzyl-(2-imidazol-1-yl-quinazolin-4-yl)-amine	DM6I5MU	Discovery agent	N.A.	Investigative	[37]
Benzyl-(2-phenyl-quinazolin-4-yl)-amine	DM3X50C	Discovery agent	N.A.	Investigative	[37]
Benzyl-(2-pyridin-3-yl-quinazolin-4-yl)-amine	DMYDGCI	Discovery agent	N.A.	Investigative	[37]
Benzyl-(2-pyridin-4-yl-quinazolin-4-yl)-amine	DMESVWC	Discovery agent	N.A.	Investigative	[37]
Benzyl-(2-thiophen-2-yl-quinazolin-4-yl)-amine	DMH318X	Discovery agent	N.A.	Investigative	[37]
CD-160130	DMT6M5E	Chronic lymphocytic leukaemia	2A82.0	Investigative	[3]
CH-3697	DM0RFTJ	Asthma	CA23	Investigative	[3]
CHF-5480	DM5T64L	Chronic obstructive pulmonary disease	CA22	Investigative	[3]
CI-1044	DMG5D6B	Discovery agent	N.A.	Investigative	[38]
isobutylmethylxanthine	DM46F5X	Discovery agent	N.A.	Investigative	[39]
KF-66490	DMOUW0A	Atopic dermatitis	EA80	Investigative	[40]
KURAIDIN	DMLDUJ1	Discovery agent	N.A.	Investigative	[41]
KURARINOL	DMRV5YE	Discovery agent	N.A.	Investigative	[41]
L-454560	DM0P4V6	Discovery agent	N.A.	Investigative	[42]
L-869298	DMKEDU6	Discovery agent	N.A.	Investigative	[43]
NITRAQUAZONE	DMVDM0Q	Discovery agent	N.A.	Investigative	[44]
OCID-2987	DM69O3S	Inflammation	1A00-CA43.1	Investigative	[3]
ROLIPRAM	DMJ03UM	Discovery agent	N.A.	Investigative	[45]
RS-14491	DMRW57G	Discovery agent	N.A.	Investigative	[45]
RS-25344	DM0W2IS	Discovery agent	N.A.	Investigative	[46]
S,S-(2-Hydroxyethyl)Thiocysteine	DMLPAD8	Discovery agent	N.A.	Investigative	[22]
SOPHOFLAVESCENOL	DM8Y1S7	Discovery agent	N.A.	Investigative	[41]
TAS-203	DM07FBL	Respiratory tract inflammation	CA07	Investigative	[3]
UCB-101333-3	DMHYORU	Discovery agent	N.A.	Investigative	[47]
ZL-N-91	DM1H865	Lung inflammation	CA40.Z	Investigative	[3]

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