Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTWHDVK)

• DTT Name: Fructose-1,6-bisphosphatase (FBP) DTT Info
• Gene Name: FBP1

Molecule-Related Drug & Molecule List

2 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Managlinat dialanetil	DMBYDNE	Type-2 diabetes	5A11	Phase 2	[1]
MB07803	DMHU8SJ	Type-2 diabetes	5A11	Phase 2	[2]

10 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
1-(2-mercaptoethyl)-3-(m-tolylsulfonyl)urea	DMIPAMW	Discovery agent	N.A.	Investigative	[3]
1-(4-aminophenylsulfonyl)-3-(2-mercaptoethyl)urea	DM4G0NH	Discovery agent	N.A.	Investigative	[3]
2,5-Anhydroglucitol-1,6-Biphosphate	DMLDHMB	Discovery agent	N.A.	Investigative	[4]
2-(4-(4-Hydroxyphenyl)thiazol-2-ylamino)phenol	DMOYT8I	Discovery agent	N.A.	Investigative	[5]
3-(4-(4-Hydroxyphenyl)thiazol-2-ylamino)phenol	DM8EH07	Discovery agent	N.A.	Investigative	[5]
4,6-Dichloro-1H-indole-2-carboxylic acid	DM62XC3	Discovery agent	N.A.	Investigative	[6]
4-(2-amino-1,3-thiazol-4-yl)phenol	DMH5CAQ	Discovery agent	N.A.	Investigative	[5]
4-(4-(4-Nitrophenyl)thiazol-2-ylamino)phenol	DMA9TCD	Discovery agent	N.A.	Investigative	[5]
Fructose-6-Phosphate	DMU5SAF	Discovery agent	N.A.	Investigative	[4]
N-(5-chlorobenzo[d]oxazol-2-yl)benzenesulfonamide	DM2TFJE	Discovery agent	N.A.	Investigative	[7]

References

• [1] MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes. Proc Natl Acad Sci U S A. 2005 May 31;102(22):7970-5.
• [2] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [3] Allosteric FBPase inhibitors gain 10(5) times in potency when simultaneously binding two neighboring AMP sites. Bioorg Med Chem Lett. 2008 Aug 15;18(16):4708-12.
• [4] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [5] A library of novel allosteric inhibitors against fructose 1,6-bisphosphatase. Bioorg Med Chem. 2009 Jun 1;17(11):3916-22.
• [6] The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
• [7] Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1807-10.