Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTWLFXU)

• DTT Name: Dystrophin messenger RNA (DMD mRNA) DTT Info
• Gene Name: DMD

Molecule-Related Drug & Molecule List

1 Approved Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eteplirsen	DM2QBHP	Duchenne dystrophy	8C70	Approved	[1]

4 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Drisapersen	DMWUN1S	Duchenne dystrophy	8C70	Phase 3	[2]
GSK2402968	DMWL2XD	Duchenne dystrophy	8C70	Phase 3	[3]
Suvodirsen	DMKGQF0	Duchenne dystrophy	8C70	Phase 2/3	[4]
PRO-044	DMFYABR	Duchenne dystrophy	8C70	Phase 2	[5]

References

• [1] 2016 FDA drug approvals. Nat Rev Drug Discov. 2017 Feb 2;16(2):73-76.
• [2] PRO-051, an antisense oligonucleotide for the potential treatment of Duchenne muscular dystrophy. Curr Opin Mol Ther. 2010 Aug;12(4):478-86.
• [3] Safety and efficacy of drisapersen for the treatment of Duchenne muscular dystrophy (DEMAND II): an exploratory, randomised, placebo-controlled phase 2 study. Lancet Neurol. 2014 Oct;13(10):987-96.
• [4] Advances in oligonucleotide drug delivery. Nat Rev Drug Discov. 2020 Oct;19(10):673-694.
• [5] Update on neuromuscular disorders in pediatric orthopaedics: Duchenne muscular dystrophy, myelomeningocele, and cerebral palsy. J Pediatr Orthop. 2014 Oct-Nov;34 Suppl 1:S44-8.