Details of the Drug-Related molecule(s) Interaction Atlas

General Information of DTT (ID: TTX0H5W)

DTT Name	Short transient receptor potential channel 4 (TRPC4) DTT Info
Gene Name	TRPC4

Molecule-Related Drug & Molecule List

Molecule-Related Drug List

Molecule Type:

DTT

DTP

DME

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

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1 Clinical Trial Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BI 1358894	DM740BS	Depression	6A70-6A7Z	Phase 2	[1]
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3 Investigative Drug(s) Transported by This DTP

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(-)-englerin A	DMPQBWY	Discovery agent	N.A.	Investigative	[2]
2-APB	DM9AKVR	Discovery agent	N.A.	Investigative	[3]
ML204	DM15YL0	Discovery agent	N.A.	Investigative	[4]
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Molecule Interaction Atlas

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References

1	Clinical pipeline report, company report or official report of Boehringer Ingelheim.
2	(-)-Englerin is a potent and selective activator of TRPC4 and TRPC5 calcium channels. Angew Chem Int Ed Engl. 2015 Mar 16;54(12):3787-91.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 489).
4	Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem. 2011 Sep 23;286(38):33436-46.