Details of Disease

General Information of Disease (ID: DIS01KTQ)

Disease Name Sciatica/lumbar radicular pain
Disease Class ME84: Spinal pain
Disease Hierarchy
DIS01GPL: Grass pollen hypersensitivity
DIS01KTQ: Sciatica/lumbar radicular pain
ICD Code
ICD-11
ICD-11: ME84.3
ICD-10
ICD-10: M54.3
Disease Identifiers
MONDO ID
MONDO_0024333
MESH ID
D012585
UMLS CUI
C0036396
MedGen ID
19893
HPO ID
HP:0011868
SNOMED CT ID
23056005

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
SP-102 DMTRQYR Phase 3 NA [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
LBP TTVQJLY Strong Biomarker [2]
TNFRSF1B TT63WSF Strong Therapeutic [3]
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This Disease Is Related to 5 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
MCF2L2 OTOGFMIH Limited Genetic Variation [4]
BLOC1S2 OTUR3E76 Strong Biomarker [5]
COL9A2 OT1ZBDBV Strong Genetic Variation [6]
DCT OTYVNTBG Strong Genetic Variation [6]
RANBP2 OTFG5CVF Strong Genetic Variation [6]
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References

1 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2 Observational multicentric study on chronic sciatic pain: clinical data from 44 Italian centers.Eur Rev Med Pharmacol Sci. 2017 Apr;21(7):1653-1664.
3 The thalidomide analgesic effect is associated with differential TNF- receptor expression in the dorsal horn of the spinal cord as studied in a rat model of neuropathic pain.Brain Res. 2012 Apr 23;1450:24-32. doi: 10.1016/j.brainres.2012.02.033. Epub 2012 Feb 22.
4 Improvement of pyridoxine-induced peripheral neuropathy by Cichorium intybus hydroalcoholic extract through GABAergic system.J Physiol Sci. 2019 May;69(3):465-476. doi: 10.1007/s12576-019-00659-8. Epub 2019 Feb 2.
5 RSEP1 is a novel gene with functional involvement in neuropathic pain behaviour.Eur J Neurosci. 2005 Sep;22(5):1090-6. doi: 10.1111/j.1460-9568.2005.04282.x.
6 Intervertebral disc degeneration in relation to the COL9A3 and the IL-1ss gene polymorphisms.Eur Spine J. 2006 May;15(5):613-9. doi: 10.1007/s00586-005-0988-1. Epub 2005 Aug 17.