Details of Disease

General Information of Disease (ID: DIS0DGX4)

• Disease Name: Aspiration pneumonia
• Synonyms: inhalation pneumonia; syndromes, acid aspiration; syndrome, acid aspiration; syndrome, Mendelson's; syndrome, Mendelson; gastric acid aspiration syndrome; aspiration pneumonia (disease); aspiration pneumonia; aspiration Pneumonias; acid aspiration syndromes; acid aspiration syndrome; Pneumonias, aspiration; Mendelsons syndrome; Mendelson's syndrome; Mendelson syndrome
• Definition: A type of lung inflammation resulting from the aspiration of food, liquid, or gastric contents into the upper respiratory tract.
• Disease Hierarchy:
  DIS1LT8E: Lung disease
  DIS0DGX4: Aspiration pneumonia
• Disease Identifiers:
  MONDO ID: MONDO_0000265
  MESH ID: D011015
  UMLS CUI: C0032290
  MedGen ID: 10814
  HPO ID: HP:0011951
  SNOMED CT ID: 422588002

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Azlocillin	DMIR5QP	Approved	Small molecular drug	[1]
Clindamycin	DM15HL8	Approved	Small molecular drug	[2]
Mezlocillin	DMY5JEP	Approved	Small molecular drug	[3]
Ticarcillin	DM4ME02	Approved	Small molecular drug	[4]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CXCL1	TTLK1RW	Strong	Biomarker	[5]
CXCL2	TTZF0K2	Strong	Biomarker	[5]
EDN1	TTJR60Z	Strong	Biomarker	[6]
IL1A	TTPM6HI	Strong	Biomarker	[7]
MYH2	TTBIL13	Strong	Genetic Variation	[8]

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ESD	OTUSIBPS	Strong	Genetic Variation	[9]
LZTR1	OTIDM6XO	Strong	CausalMutation	[10]

References

• [1] Azlocillin FDA Label
• [2] Clindamycin FDA Label
• [3] Mezlocillin FDA Label
• [4] Ticarcillin FDA Label
• [5] Superimposed gastric aspiration increases the severity of inflammation and permeability injury in a rat model of lung contusion.J Surg Res. 2009 Aug;155(2):273-82. doi: 10.1016/j.jss.2008.08.020. Epub 2008 Sep 16.
• [6] Hydrochloric acid aspiration increases right ventricular systolic pressure in rats.Eur J Anaesthesiol. 2009 Apr;26(4):285-92. doi: 10.1097/EJA.0b013e32831ac614.
• [7] Characterization of the innate immune response to chronic aspiration in a novel rodent model.Respir Res. 2007 Nov 27;8(1):87. doi: 10.1186/1465-9921-8-87.
• [8] Congenital myopathy due to myosin heavy chain 2 mutation presenting as chronic aspiration pneumonia in infancy.Neuromuscul Disord. 2017 Oct;27(10):947-950. doi: 10.1016/j.nmd.2017.06.015. Epub 2017 Jun 27.
• [9] Preoperative Pulmonary Function Tests Predict Aspiration Pneumonia After Gastric Endoscopic Submucosal Dissection.Dig Dis Sci. 2017 Nov;62(11):3084-3090. doi: 10.1007/s10620-017-4750-4. Epub 2017 Sep 6.
• [10] Autosomal recessive Noonan syndrome associated with biallelic LZTR1 variants.Genet Med. 2018 Oct;20(10):1175-1185. doi: 10.1038/gim.2017.249. Epub 2018 Feb 22.