Details of Disease

Disease Name

Diverticulitis

inflammation of digestive tract diverticulum; digestive tract diverticulum inflammation

Definition

An infection that develops in the diverticula of the intestinal tract. Signs and symptoms include abdominal pain, fever, and leukocytosis.

Disease Hierarchy

DISWD40R: Disease

DISGPMUQ: Intestinal disorder

DIS184KT: Skin inflammation

DIS1AK7Q: Diverticulitis

Disease Identifiers

MONDO ID

MONDO_0004235

MESH ID

D004238

UMLS CUI

C0012813

MedGen ID

41629

SNOMED CT ID

18126004

General Information of Disease (ID: DIS1AK7Q)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Mesalazine	DMOL5IU	Approved	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 4 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ARSA	TTYQANR	Strong	Genetic Variation	[2]
CALCB	TTUZ9GV	Strong	Genetic Variation	[3]
PDE7B	TTWIEY9	Strong	Genetic Variation	[3]
TNFSF15	TTEST6I	Strong	Genetic Variation	[4]
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This Disease Is Related to 7 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
IL18BP	OTW0LRYZ	Limited	Altered Expression	[5]
LAMB4	OT0NOOB2	Limited	Altered Expression	[6]
PHOX2B	OT3SFR2O	Limited	Altered Expression	[7]
SAG	OTDNS3ZQ	Limited	Biomarker	[8]
ACAD8	OT3JI5GB	Strong	Biomarker	[9]
ARHGAP15	OT9CKHDC	Strong	Genetic Variation	[3]
COLQ	OT4BHUGQ	Strong	Genetic Variation	[3]
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⏷ Show the Full List of 7 DOT(s)

References

1	Colonic diverticular disease. Nat Rev Dis Primers. 2020 Mar 26;6(1):20.
2	Safety and feasibility of laparoscopic sigmoid resection without diversion in perforated diverticulitis.Surg Endosc. 2020 Mar;34(3):1336-1342. doi: 10.1007/s00464-019-06910-y. Epub 2019 Jun 17.
3	Sequence variants in ARHGAP15, COLQ and FAM155A associate with diverticular disease and diverticulitis.Nat Commun. 2017 Jun 6;8:15789. doi: 10.1038/ncomms15789.
4	Diverticulitis and Crohn's disease have distinct but overlapping tumor necrosis superfamily 15haplotypes.J Surg Res. 2017 Jun 15;214:262-269. doi: 10.1016/j.jss.2017.02.030. Epub 2017 Feb 27.
5	Interleukin-18 is increased only in a minority of patients with active Crohn's disease.Int J Colorectal Dis. 2007 Sep;22(9):1013-20. doi: 10.1007/s00384-007-0282-2. Epub 2007 Feb 21.
6	Identification of a rare LAMB4 variant associated with familial diverticulitis through exome sequencing.Hum Mol Genet. 2017 Aug 15;26(16):3212-3220. doi: 10.1093/hmg/ddx204.
7	Altered enteric expression of the homeobox transcription factor Phox2b in patients with diverticular disease.United European Gastroenterol J. 2019 Apr;7(3):349-357. doi: 10.1177/2050640618824913. Epub 2019 Jan 16.
8	Randomised clinical trial: mesalazine versus placebo in the prevention of diverticulitis recurrence.Aliment Pharmacol Ther. 2017 Aug;46(3):282-291. doi: 10.1111/apt.14152. Epub 2017 May 23.
9	Elevated Venous Thromboembolism Risk Following Colectomy for IBD Is Equal to Those for Colorectal Cancer for Ninety Days After Surgery.Dis Colon Rectum. 2018 Mar;61(3):375-381. doi: 10.1097/DCR.0000000000001036.