Details of Disease

General Information of Disease (ID: DIS3M6SR)

Disease Name Preterm premature rupture of the membranes
Synonyms PPROM; preterm premature rupture of the membranes, susceptibility to; preterm premature rupture of the membranes
Definition A female reproductive system disease characterized by rupture of chorioamniotic membranes before 37 weeks of gestation.
Disease Hierarchy
DISYKSRF: Genetic disease
DISXEPZF: Gynecological disease
DIS3M6SR: Preterm premature rupture of the membranes
Disease Identifiers
MONDO ID
MONDO_0012511
MESH ID
C563032
UMLS CUI
C0729264
OMIM ID
610504
MedGen ID
147582
HPO ID
HP:6000310
SNOMED CT ID
312974005

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Erythromycin DM4K7GQ Approved Small molecular drug [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
SERPINH1 TTPSWQG Strong Biomarker [2]
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References

1 Erythromycin FDA Label
2 Homozygosity for a missense mutation in SERPINH1, which encodes the collagen chaperone protein HSP47, results in severe recessive osteogenesis imperfecta.Am J Hum Genet. 2010 Mar 12;86(3):389-98. doi: 10.1016/j.ajhg.2010.01.034. Epub 2010 Feb 25.