Details of Disease

General Information of Disease (ID: DIS4PDHI)

Disease Name Adrenocortical carcinoma, hereditary
Synonyms adrenocortical carcinoma, paediatric; ADCC; adrenocortical carcinoma, pediatric; adrenocortical carcinoma, hereditary; hereditary adrenal cortex carcinoma
Definition An instance of adrenal cortex carcinoma that is caused by an inherited modification of the individual's genome.
Disease Hierarchy
DISTN8X8: Hereditary renal cell carcinoma
DISZF4HX: Adrenocortical carcinoma
DIS4PDHI: Adrenocortical carcinoma, hereditary
Disease Identifiers
MONDO ID
MONDO_0008734
UMLS CUI
C1859972
OMIM ID
202300
MedGen ID
348508

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
TP53 TT7SBF5 Strong Autosomal dominant [1]
TP53 TT12KOD Strong Genetic Variation [2]
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This Disease Is Related to 2 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
DKK4 OTWCCVF6 Strong Genetic Variation [3]
KRT13 OTTYSKGX Definitive Biomarker [2]
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References

1 Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications. Hum Mutat. 2017 May;38(5):600-608. doi: 10.1002/humu.23183. Epub 2017 Feb 13.
2 Molecular and clinical differences between adenocarcinomas of the esophagus and of the gastric cardia.Am J Pathol. 2001 Jan;158(1):33-40. doi: 10.1016/S0002-9440(10)63941-7.
3 Genetic Variants in the Wingless Antagonist Genes (sFRP, DKK, and Axin2) Predict the Overall Survival and Prognosis of North Indian Lung Cancer Patients Treated with Platinum-Based Doublet Chemotherapy.Cancer Biother Radiopharm. 2018 Dec;33(10):466-477. doi: 10.1089/cbr.2018.2491. Epub 2018 Oct 20.