Details of Disease

General Information of Disease (ID: DIS502ED)

Disease Name Uterine corpus sarcoma
Synonyms
uterine sarcoma; sarcoma of the uterus; uterine sarcoma/mesenchymal; sarcoma of the uterine corpus; sarcoma of the corpus uteri; corpus uteri sarcoma; uterine body sarcoma; uterus sarcoma; sarcoma of corpus uteri; sarcoma of the uterine body; sarcoma of the body of uterus; sarcoma of uterine body; sarcoma of uterus; sarcoma of body of uterus; sarcoma of uterine corpus; body of uterus sarcoma
Definition A malignant mesenchymal neoplasm arising from the wall of the uterine corpus (uterine body). The most representative examples are leiomyosarcoma and endometrial stromal sarcoma.
Disease Hierarchy
DISZDG3U: Sarcoma
DISDHSN8: Uterine corpus cancer
DIS502ED: Uterine corpus sarcoma
Disease Identifiers
MONDO ID
MONDO_0005210
UMLS CUI
C0338113
MedGen ID
137837
Orphanet ID
213620
SNOMED CT ID
1162311007

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 3 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
NACC1 TT4AQ5F moderate Biomarker [1]
PGRMC1 TTY3LAZ moderate Biomarker [2]
SMARCA4 TTVQEZS Moderate Autosomal recessive [3]
------------------------------------------------------------------------------------
This Disease Is Related to 1 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
ME1 DE97WM8 moderate Biomarker [4]
------------------------------------------------------------------------------------
This Disease Is Related to 3 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
MKS1 OT83W5PB moderate Biomarker [4]
NUTM2A OTQ4VQXE moderate Genetic Variation [5]
SMARCA4 OT68WOPQ Moderate Autosomal recessive [3]
------------------------------------------------------------------------------------

References

1 NAC1, a BTB/POZ protein overexpressed in uterine sarcomas.Anticancer Res. 2012 Sep;32(9):3841-5.
2 PGRMC1 contributes to doxorubicin-induced chemoresistance in MES-SA uterine sarcoma.Cell Mol Life Sci. 2015 Jun;72(12):2395-409. doi: 10.1007/s00018-014-1831-9. Epub 2015 Jan 18.
3 SMARCA4 inactivation defines a subset of undifferentiated uterine sarcomas with rhabdoid and small cell features and germline mutation association. Mod Pathol. 2019 Nov;32(11):1675-1687. doi: 10.1038/s41379-019-0303-z. Epub 2019 Jun 12.
4 Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody-Drug Conjugates.J Am Chem Soc. 2018 Mar 14;140(10):3690-3711. doi: 10.1021/jacs.7b12692. Epub 2018 Jan 30.
5 YWHAE-rearranged high-grade endometrial stromal sarcoma: Two-center case series and response to chemotherapy.Gynecol Oncol. 2017 Jun;145(3):531-535. doi: 10.1016/j.ygyno.2017.03.021. Epub 2017 Apr 5.