Details of Drug Off-Target (DOT)

General Information of Drug Off-Target (DOT) (ID: OTQ4VQXE)

• DOT Name: NUT family member 2A (NUTM2A)
• Gene Name: NUTM2A
• Related Disease:
  Neoplasm
  Advanced cancer
  Uterine corpus sarcoma
  Malignant soft tissue neoplasm
  Sarcoma
• UniProt ID: NTM2A_HUMAN
• Pfam ID: PF12881
• Sequence:
  MEVKGPSGRSFCCESEGQFKSCLKRHTPSLLLPSSWKGNSGSCLMAKALHRMSPTPNSCP
  LPLPLCRMSGVLCSRNLFTFKFSLFQLDSGASGEPGHSLGLTLGFSHCGNCQTAVVSAQP
  EGMASNGAYPALGPGVTANPGTSLSVFTALPFTTPAPGPAHGPLLVTAGAPPGGPLVLST
  LPSTPLVTEQDGCGPSGAGASNVFVQMRTEVGPVKAAQAQTLVLTQAPLVWQAPGALCGG
  VVCPPPLLLAAAPVVPVMAAQVVGGTQACEGGWSQGLPLPPPPPPAAQLPPIVSQGNAGP
  WPQGAHGEGSLASSQAKAPPDDSCNPRSVYENFRLWQHYKPLARRHLPQSPDTEALSCFL
  IPVLRSLARRKPTMTLEEGLWRAMREWQHTSNFDRMIFYEMAEKFLEFEAEEEMQIQKSQ
  WMKGPQCLPPPATPRLEPRGPPAPEVVKQPVYLPSKAGPKAPTACLPPPRPQRPVTKARR
  PPPRPHRRAETKARLPPPRPQRPAETKVPEEIPPEVVQEYVDIMEELLGPSLGATGEPEK
  QREEGEVKQPQEEDWTPPDPGLLSYTDKLCSQKDFVTKVEAVIHPQFLEELLSPDPQMDF
  LALSQELEQEEGLTLAQLVEKRLLPLKEKQHARAAPSRGTARLDSSSSKFAAGQGAERDV
  PVPQQGVGMETCPPQTTARDSQGRGRAHTGMARSKDSVVLLGCQDSPGLRAARPTSPPQD
  HRPTCPGVGTKDALDLPGGSPVRESHGLAQGSSEEEELPSLAFLLGSQHKLLPWWLPQSP
  VPASGLLSPEKWGPQGTHQFPSAERRGLNLAPSPANKAKKRPLFGSLSPAEKTPHPGPGL
  RVSGEQSLTWGLGGPSQSQKRKGDPLVSRKEKKQRCSQ

Molecular Interaction Atlas (MIA) of This DOT

5 Disease(s) Related to This DOT

Disease Name	Disease ID	Evidence Level	Mode of Inheritance	REF
Neoplasm	DISZKGEW	Strong	Genetic Variation	[1]
Advanced cancer	DISAT1Z9	moderate	Genetic Variation	[2]
Uterine corpus sarcoma	DIS502ED	moderate	Genetic Variation	[3]
Malignant soft tissue neoplasm	DISTC6NO	Limited	Genetic Variation	[1]
Sarcoma	DISZDG3U	Limited	Genetic Variation	[1]

4 Drug(s) Affected the Gene/Protein Processing of This DOT

Drug Name	Drug ID	Highest Status	Interaction	REF
Cisplatin	DMRHGI9	Approved	Cisplatin decreases the expression of NUT family member 2A (NUTM2A).	[4]
Urethane	DM7NSI0	Phase 4	Urethane increases the expression of NUT family member 2A (NUTM2A).	[5]
PMID28460551-Compound-2	DM4DOUB	Patented	PMID28460551-Compound-2 decreases the expression of NUT family member 2A (NUTM2A).	[6]
Bisphenol A	DM2ZLD7	Investigative	Bisphenol A increases the expression of NUT family member 2A (NUTM2A).	[7]

References

• [1] NUTM2A-CIC fusion small round cell sarcoma: a genetically distinct variant of CIC-rearranged sarcoma.Hum Pathol. 2017 Jul;65:225-230. doi: 10.1016/j.humpath.2017.01.012. Epub 2017 Feb 8.
• [2] Frequent expression of KIT in endometrial stromal sarcoma with YWHAE genetic rearrangement.Mod Pathol. 2014 May;27(5):751-7. doi: 10.1038/modpathol.2013.199. Epub 2013 Nov 1.
• [3] YWHAE-rearranged high-grade endometrial stromal sarcoma: Two-center case series and response to chemotherapy.Gynecol Oncol. 2017 Jun;145(3):531-535. doi: 10.1016/j.ygyno.2017.03.021. Epub 2017 Apr 5.
• [4] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [5] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [6] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [7] Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.