Details of Disease

General Information of Disease (ID: DIS53TUF)

Disease Name Non-arteritic anterior ischemic optic neuropathy
Synonyms nonarteritic anterior ischemic optic neuropathy; nonarteritic anterior ischaemic optic neuropathy; non-arteritic aion; NAION
Disease Class 9C40: Optic nerve disorder
Disease Hierarchy
DISOFUFW: Ischemic optic neuropathy
DIS53TUF: Non-arteritic anterior ischemic optic neuropathy
ICD Code
ICD-11
ICD-11: 9C40.40
Expand ICD-11
'9C40.40
Disease Identifiers
MONDO ID
MONDO_0000499
MESH ID
D018917
UMLS CUI
C1852242
MedGen ID
338887
HPO ID
HP:0007634
Orphanet ID
415300

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Magnesium Sulfate DMVEK07 Approved Small molecular drug [1]
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This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
QPI-1007 DMUWXEB Phase 3 siRNA drug [2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
GP1BA TTVB0Q9 Strong Genetic Variation [3]
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This Disease Is Related to 2 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
PLXNA2 OTNNBJMQ Strong Biomarker [4]
POU4F1 OTMHYGWQ Strong Biomarker [5]
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References

1 Magnesium Sulfate FDA Label
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Bilateral NAION and GPIb gene.BMC Ophthalmol. 2019 Jan 7;19(1):5. doi: 10.1186/s12886-018-1010-0.
4 Macular Vascularity in Ischemic Optic Neuropathy Compared to Glaucoma by Projection-Resolved Optical Coherence Tomography Angiography.Am J Ophthalmol. 2020 Jan;209:27-34. doi: 10.1016/j.ajo.2019.09.015. Epub 2019 Sep 25.
5 Increased ER Stress After Experimental Ischemic Optic Neuropathy and Improved RGC and Oligodendrocyte Survival After Treatment With Chemical Chaperon.Invest Ophthalmol Vis Sci. 2019 May 1;60(6):1953-1966. doi: 10.1167/iovs.18-24890.