Details of Disease | DrugMAP

General Information of Disease (ID: DIS67XU0)

Disease Name	Obsolete mitochondrial complex II deficiency
Definition	Created new class that is child of OMIMPS.
Disease Hierarchy	DIS01GPL: Grass pollen hypersensitivity DIS67XU0: Obsolete mitochondrial complex II deficiency

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
SDHD	TTVH9W8	Moderate	Autosomal recessive	[1]
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This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SDHA	OTOJ8QFF	Supportive	Autosomal recessive	[2]
SDHB	OTRE1M1T	Supportive	Autosomal recessive	[2]
SDHAF1	OTDG5VW7	Moderate	Autosomal recessive	[1]
SDHD	OTYZ8XRH	Moderate	Autosomal recessive	[1]
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References

1	Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications. Hum Mutat. 2017 May;38(5):600-608. doi: 10.1002/humu.23183. Epub 2017 Feb 13.
2	Recessive germline SDHA and SDHB mutations causing leukodystrophy and isolated mitochondrial complex II deficiency. J Med Genet. 2012 Sep;49(9):569-77. doi: 10.1136/jmedgenet-2012-101146.