Details of Disease

General Information of Disease (ID: DIS7MS3M)

Disease Name	Autoimmune haemolytic anaemia
Synonyms	anemia, autoimmune hemolytic; immuno-hemolytic anaemia; familial auto-immune hemolytic anaemia (subtype); acquired autoimmune hemolytic anemia; familial auto-immune hemolytic anemia (subtype); anemia hemolytic autoimmune; idiopathic autoimmune hemolytic anemia; anaemia hemolytic autoimmune; immuno-hemolytic anemia; idiopathic autoimmune hemolytic anaemia; acquired autoimmune hemolytic anaemia; AHA; autoimmune haemolytic anaemia; AIHA; Anemia, Hemolytic, Acquired Autoimmune; autoimmune haemolytic anemia; autoimmune hemolytic anemia
Disease Class	3A20: Acquired haemolytic anaemia
Definition	Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder in which various types of auto-antibodies are directed against red blood cells causing their survival to be shortened and resulting in hemolytic anemia.
Disease Hierarchy	DIS803XQ: Hemolytic anemia DIS99AR2: Autoimmune disorder of blood DIS7MS3M: Autoimmune haemolytic anaemia
ICD Code	ICD-11 ICD-11: 3A20
Disease Identifiers	MONDO ID MONDO_0020108 UMLS CUI C0002880 OMIM ID 205700 MedGen ID 1918 HPO ID HP:0001890 Orphanet ID 98375 SNOMED CT ID 413603009

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 8 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Betamethasone	DMAHJEF	Approved	Small molecular drug	[1]
Cortisone Acetate	DMG8K57	Approved	Small molecular drug	[2]
Dexamethasone	DMMWZET	Approved	Small molecular drug	[3]
Hydrocortisone	DMGEMB7	Approved	Small molecular drug	[4]
Methylprednisolone	DM4BDON	Approved	Small molecular drug	[5]
Prednisolone	DMQ8FR2	Approved	Small molecular drug	[6]
Prednisone	DM2HG4X	Approved	Small molecular drug	[7]
Triamcinolone	DM98IXF	Approved	Small molecular drug	[8]
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⏷ Show the Full List of 8 Drug(s)

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Nipocalimab?	DM0DYAX	Phase 3	Monoclonal antibody	[9]
SAR445088	DMQV3IM	Phase 2	NA	[10]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 6 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
SIRPA	TTBRJS9	Limited	Altered Expression	[11]
SLC14A1	TTWVJU1	Limited	Biomarker	[12]
ADA	TTLP57V	Strong	Genetic Variation	[13]
CASP10	TTX5HEK	Strong	Biomarker	[14]
CTLA4	TTI2S1D	Strong	Genetic Variation	[15]
RHD	TTLCKI8	Strong	Biomarker	[16]
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⏷ Show the Full List of 6 DTT(s)

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
MRGPRF	OT74OZ2Z	Strong	Biomarker	[17]
RAG2	OTG9UYTW	Strong	Genetic Variation	[18]
RBFOX2	OTXY1WVH	Strong	Biomarker	[17]
RNF112	OT0Q9OUQ	Strong	Biomarker	[19]
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References

1	Betamethasone FDA Label
2	Cortisone acetate FDA Label
3	Dexamethasone FDA Label
4	Hydrocortisone FDA Label
5	Methylprednisolone FDA Label
6	Prednisolone FDA Label
7	Prednisone FDA Label
8	Triamcinolone FDA Label
9	ClinicalTrials.gov (NCT04119050) Efficacy and Safety of M281 in Adults With Warm Autoimmune Hemolytic Anemia: A Multicenter, Randomized, Double-blind, Placebo-controlled Study With a Long-term Open-label Extension. U.S.National Institutes of Health.
10	ClinicalTrials.gov (NCT04802057) An Open-label, Long-term, Safety and Tolerability Study of SAR445088 in Participants With Cold Agglutinin Disease Previously Treated With SAR445088 or Never Treated With SAR445088. U.S.National Institutes of Health.
11	Expression levels of CD47, CD35, CD55, and CD59 on red blood cells and signal-regulatory protein-alpha,beta on monocytes from patients with warm autoimmune hemolytic anemia.Transfusion. 2009 Jan;49(1):154-60. doi: 10.1111/j.1537-2995.2008.01936.x. Epub 2008 Oct 2.
12	Acute hemolytic anemia associated with a chlorpropamide-induced apparent auto-anti-Jka.Transfusion. 1984 May-Jun;24(3):206-9. doi: 10.1046/j.1537-2995.1984.24384225022.x.
13	Heterozygous Mutation in Adenosine Deaminase Gene in a Patient With Severe Lymphopenia Following Corticosteroid Treatment of Autoimmune Hemolytic Anemia.Front Pediatr. 2018 Oct 1;6:272. doi: 10.3389/fped.2018.00272. eCollection 2018.
14	Exonic deletion of CASP10 in a patient presenting with systemic juvenile idiopathic arthritis, but not with autoimmune lymphoproliferative syndrome type IIa.Int J Immunogenet. 2011 Aug;38(4):287-93. doi: 10.1111/j.1744-313X.2011.01005.x. Epub 2011 Mar 7.
15	Autoimmune hemolytic anemia associated with the use of immune checkpoint inhibitors for cancer: 68 cases from the Food and Drug Administration database and review.Eur J Haematol. 2019 Feb;102(2):157-162. doi: 10.1111/ejh.13187. Epub 2018 Nov 29.
16	Molecular determination of RhD phenotype by DNA typing: clinical applications.Ann Clin Biochem. 2000 Nov;37 ( Pt 6):781-9. doi: 10.1258/0004563001900101.
17	AN UNUSUAL CASE OF FAMILIAL SYSTEMIC LUPUS ERYTHEMATOSUS WITH DISTAL RENAL TUBULAR ACIDOSIS AND HEMOLYTIC ANEMIA.Iran J Kidney Dis. 2019 Sep;13(5):337-339.
18	Late Onset Hypomorphic RAG2 Deficiency Presentation with Fatal Vaccine-Strain VZV Infection.J Clin Immunol. 2015 Nov;35(8):754-60. doi: 10.1007/s10875-015-0207-8. Epub 2015 Oct 29.
19	Biologic false-positive serologic tests for syphilis and other serologic abnormalities in autoimmune hemolytic anemia and thrombocytopenic purpura.Medicine (Baltimore). 1989 Mar;68(2):67-84. doi: 10.1097/00005792-198903000-00001.