Details of Disease

General Information of Disease (ID: DIS7UMEC)

Disease Name Metabolic acidosis
Disease Class 5C73: Acidosis
Disease Hierarchy
DISJQTX1: Acidosis
DIS7UMEC: Metabolic acidosis
ICD Code
ICD-11
ICD-11: 5C73
ICD-10
ICD-10: E87.2
ICD-9
ICD-9: 276.2
Expand ICD-11
'5C73.Z
Expand ICD-9
276.2
Disease Identifiers
MONDO ID
MONDO_0000440
UMLS CUI
C0220981
MedGen ID
65117
HPO ID
HP:0001942
SNOMED CT ID
59455009

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Sodium bicarbonate DMMU6BJ Approved Small molecular drug [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 4 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
SLC38A3 TTMAVJQ Limited Therapeutic [2]
EDN1 TTJR60Z moderate Therapeutic [3]
NFE2L2 TTA6ZN2 moderate Biomarker [4]
RHCG TTN5MZ3 moderate Biomarker [5]
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This Disease Is Related to 2 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC4A1 DTB0Q3P moderate Biomarker [6]
SLC9A4 DTU8PXI moderate Biomarker [7]
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This Disease Is Related to 2 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
DAB2 OTRMQTMZ moderate Biomarker [8]
MYH9 OT94Z706 moderate Biomarker [8]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4507).
2 Glucocorticoids have a role in renal cortical expression of the SNAT3 glutamine transporter during chronic metabolic acidosis. Am J Physiol Renal Physiol. 2007 Jan;292(1):F448-55.
3 Adrenomedullin and adrenomedullin binding protein-1 prevent metabolic acidosis after uncontrolled hemorrhage in rats.Crit Care Med. 2007 Mar;35(3):912-8. doi: 10.1097/01.CCM.0000257327.61829.34.
4 NRF2 regulates the glutamine transporter Slc38a3 (SNAT3) in kidney in response to metabolic acidosis.Sci Rep. 2018 Apr 4;8(1):5629. doi: 10.1038/s41598-018-24000-2.
5 Renal expression of the ammonia transporters, Rhbg and Rhcg, in response to chronic metabolic acidosis.Am J Physiol Renal Physiol. 2006 Feb;290(2):F397-408. doi: 10.1152/ajprenal.00162.2005. Epub 2005 Sep 6.
6 The calcineurin inhibitor FK506 (tacrolimus) is associated with transient metabolic acidosis and altered expression of renal acid-base transport proteins.Am J Physiol Renal Physiol. 2009 Aug;297(2):F499-509. doi: 10.1152/ajprenal.90489.2008. Epub 2009 May 13.
7 NHE4 is critical for the renal handling of ammonia in rodents.J Clin Invest. 2010 Jun;120(6):1895-904. doi: 10.1172/JCI36581. Epub 2010 May 17.
8 Proteomic profiling of the effect of metabolic acidosis on the apical membrane of the proximal convoluted tubule.Am J Physiol Renal Physiol. 2012 Jun 1;302(11):F1465-77. doi: 10.1152/ajprenal.00390.2011. Epub 2012 Feb 22.