Details of Disease

Disease Name

Neonatal sepsis

Definition

Bacterial infection in the bloodstream of newborn infants younger than 28 days old.

Disease Hierarchy

DIS6N9RZ: Bacteremia

DIS8Q3VE: Neonatal sepsis

Disease Identifiers

MONDO ID

MONDO_0700217

MESH ID

D000071074

UMLS CUI

C0456103

MedGen ID

96816

HPO ID

HP:0040187

SNOMED CT ID

206376005

General Information of Disease (ID: DIS8Q3VE)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 6 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Amikacin	DM5PDRB	Approved	Small molecular drug	[1]
Cefotaxime	DMEB837	Approved	NA	[2]
Fusidic Acid	DMWVCF3	Approved	Small molecular drug	[3]
Gentamicin	DMKINJO	Approved	Small molecular drug	[4]
Tobramycin	DMUI0CH	Approved	Small molecular drug	[5]
Vancomycin	DM3JFIH	Approved	NA	[6]
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⏷ Show the Full List of 6 Drug(s)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Benzylpenicillin	DMS9503	Phase 3	Small molecular drug	[7]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
FCGR1A	TTZK4I3	Strong	Biomarker	[8]
MFGE8	TT1GLAJ	Strong	Biomarker	[9]
PRSS1	TT2WR1T	Strong	Genetic Variation	[10]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CIRBP	OTXWTPBL	Strong	Biomarker	[11]
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References

1	Amikacin FDA Label
2	Cefotaxime FDA Label
3	Microbiological Characteristics and Resistance Patterns in a Neonatal Intensive Care Unit: A Retrospective Surveillance Study. Cureus. 2024 Mar 12;16(3):e56027.
4	Gentamicin FDA Label
5	Tobramycin FDA Label
6	Vancomycin FDA Label
7	Antibiotic regimens for early-onset neonatal sepsis. Cochrane Database Syst Rev. 2021 May 17;5(5):CD013837.
8	Utility of presepsin, soluble triggering receptor expressed on myeloid cells-1, and neutrophil CD64 for early detection of neonatal sepsis.Infect Drug Resist. 2019 Jan 29;12:311-319. doi: 10.2147/IDR.S191533. eCollection 2019.
9	Treatment with milk fat globule epidermal growth factor-factor 8 (MFG-E8) reduces inflammation and lung injury in neonatal sepsis.Surgery. 2017 Aug;162(2):349-357. doi: 10.1016/j.surg.2017.02.006. Epub 2017 Mar 23.
10	High serum trypsin levels and the -409 T/T genotype of PRSS1 gene are susceptible to neonatal sepsis.Inflammation. 2014 Oct;37(5):1751-6. doi: 10.1007/s10753-014-9904-3.
11	C23, an oligopeptide derived from cold-inducible RNA-binding protein, suppresses inflammation and reduces lung injury in neonatal sepsis.J Pediatr Surg. 2019 Oct;54(10):2053-2060. doi: 10.1016/j.jpedsurg.2018.12.020. Epub 2019 Jan 4.