Details of Disease

General Information of Disease (ID: DISAOX93)

• Disease Name: Pyelonephritis
• Synonyms: pyometrium; kidney infection
• Definition: An inflammatory process affecting the kidney. The cause is most often bacterial, but may also be fungal in nature. Signs and symptoms may include fever, chills, flank pain, painful and frequent urination, cloudy or bloody urine, and confusion.
• Disease Hierarchy:
  DIS9BYHO: Uterine inflammatory disease
  :
  DISNNJTF: Bacterial urinary tract infection
  DISAOX93: Pyelonephritis
• Disease Identifiers:
  MONDO ID: MONDO_0006939
  MESH ID: D011704
  UMLS CUI: C0034186
  MedGen ID: 19590
  HPO ID: HP:0012330
  SNOMED CT ID: 45816000

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Doripenem	DM9UCJK	Approved	Small molecular drug	[1]
Levofloxacin	DMS60RB	Approved	Small molecular drug	[2]
Norfloxacin	DMIZ6W2	Approved	Small molecular drug	[3]
Ofloxacin	DM0VQN3	Approved	Small molecular drug	[4]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 6 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
B2M	TTY7FKA	moderate	Biomarker	[5]
BMP7	TTKOBRA	moderate	Biomarker	[6]
CRP	TTWRN6M	moderate	Biomarker	[5]
DPEP1	TTYUENF	Strong	Altered Expression	[7]
PIM1	TTTN5QW	Strong	Biomarker	[8]
SFTPD	TTGLMU7	Strong	Biomarker	[9]

This Disease Is Related to 1 DME Molecule(s)

Gene Name	DME ID	Evidence Level	Mode of Inheritance	REF
CYB5A	DE9A2LB	moderate	Biomarker	[10]

This Disease Is Related to 12 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
REG3G	OTLIUY8Z	Limited	Altered Expression	[11]
IL3	OT0CQ35N	moderate	Biomarker	[12]
MRPS30	OTDXIAGG	Strong	Biomarker	[13]
MTPAP	OT6HQ02S	Strong	Biomarker	[13]
PAPOLA	OTPHD65D	Strong	Biomarker	[13]
PAPOLG	OTIV69YA	Strong	Genetic Variation	[14]
PDAP1	OTJSWMOD	Strong	Biomarker	[13]
PRADC1	OTDWLPO9	Strong	Altered Expression	[15]
PROZ	OTI3TXBE	Strong	Biomarker	[16]
RBMS2	OTTX6071	Strong	Biomarker	[17]
RNASE7	OTIXO0Z4	Strong	Altered Expression	[18]
SCNN1G	OTSJYQVQ	Strong	Biomarker	[19]

References

• [1] Doripenem FDA Label
• [2] Levofloxacin FDA Label
• [3] Norfloxacin FDA Label
• [4] Ofloxacin FDA Label
• [5] A model of experimental acute hematogenous pyelonephritis in the rat.Folia Med (Plovdiv). 2011 Apr-Jun;53(2):63-8. doi: 10.2478/v10153-010-0039-5.
• [6] Downregulation of the expression of bone morphogenetic protein 7 in experimental pyelonephritis.Pediatr Nephrol. 2005 Sep;20(9):1230-6. doi: 10.1007/s00467-005-1927-4. Epub 2005 Jul 21.
• [7] Unexpected Pyelonephritis Incidentally Revealed on 99mTc MDP Bone Scintigraphy.Clin Nucl Med. 2017 Dec;42(12):978-979. doi: 10.1097/RLU.0000000000001860.
• [8] Conditional transgenic expression of PIM1 kinase in prostate induces inflammation-dependent neoplasia.PLoS One. 2013;8(4):e60277. doi: 10.1371/journal.pone.0060277. Epub 2013 Apr 2.
• [9] Surfactant protein D inhibits lipopolysaccharide-induced monocyte chemoattractant protein-1 expression in human renal tubular epithelial cells: implication for tubulointerstitial fibrosis.Clin Exp Immunol. 2012 Mar;167(3):514-22. doi: 10.1111/j.1365-2249.2011.04521.x.
• [10] [Disorders of the processes of protein biosynthesis and a decrease in the content of cytochromes P-450 and b5 in the microsomal fraction of rat kidney in the dynamics of development of acute pyelonephritis].Ukr Biokhim Zh (1978). 1998 Jul-Aug;70(4):139-42.
• [11] Expression and Significance of the HIP/PAP and RegIII Antimicrobial Peptides during Mammalian Urinary Tract Infection.PLoS One. 2015 Dec 10;10(12):e0144024. doi: 10.1371/journal.pone.0144024. eCollection 2015.
• [12] Global gene expression profiling of renal scarring in a rat model of pyelonephritis.Pediatr Nephrol. 2008 Jul;23(7):1059-71. doi: 10.1007/s00467-007-0717-6. Epub 2008 Jan 23.
• [13] Characterization of adhesion associated surface properties of uropathogenic Escherichia coli.Folia Microbiol (Praha). 1994;39(5):373-7. doi: 10.1007/BF02814441.
• [14] Gene products specifying adhesion of uropathogenic Escherichia coli are minor components of pili.Proc Natl Acad Sci U S A. 1986 Mar;83(6):1891-5. doi: 10.1073/pnas.83.6.1891.
• [15] Phase-variation of pyelonephritis-associated pili in Escherichia coli: evidence for transcriptional regulation.EMBO J. 1989 Feb;8(2):613-20. doi: 10.1002/j.1460-2075.1989.tb03416.x.
• [16] Pyelonephritis during pregnancy: a cause for an acquired deficiency of protein Z.J Matern Fetal Neonatal Med. 2008 Sep;21(9):629-37. doi: 10.1080/14767050802214659.
• [17] dra-related X adhesins of gestational pyelonephritis-associated Escherichia coli recognize SCR-3 and SCR-4 domains of recombinant decay-accelerating factor.Infect Immun. 1995 May;63(5):1663-8. doi: 10.1128/iai.63.5.1663-1668.1995.
• [18] Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract.Kidney Int. 2013 Apr;83(4):615-25. doi: 10.1038/ki.2012.410. Epub 2013 Jan 9.
• [19] Transient pseudohypoaldosteronism in infancy secondary to urinary tract infection.J Paediatr Child Health. 2017 May;53(5):458-463. doi: 10.1111/jpc.13481. Epub 2017 Feb 24.