Details of Disease

General Information of Disease (ID: DISCL1WZ)

Disease Name	Ear disease
Synonyms	Ear disorder; ear disease; disease of ear; disorder of ear; Ear disease; disease or disorder of ear; ear disease or disorder
Disease Class	AA0Y-AC0Z: Ear disease
Definition	A disease that involves the ear.
Disease Hierarchy	DISUFSPX: Otorhinolaryngologic disease DISWD40R: Disease DISCL1WZ: Ear disease
ICD Code	ICD-11 ICD-11: AA0Y-AC0Z Expand ICD-11 '10
Disease Identifiers	MONDO ID MONDO_0021205 MESH ID D004427 UMLS CUI C0013447 MedGen ID 3946 SNOMED CT ID 25906001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Carbamide peroxide	DMPQWRL	Approved	Small molecular drug	[1]
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This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Fibroblast growth factor	DMQEDME	Investigative	NA	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTP Molecule(s)

Gene Name	DTP ID	Evidence Level	Mode of Inheritance	REF
SLC26A2	DTFSLX5	Strong	Biomarker	[3]
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This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CLRN1	OT1ADI7Q	Strong	Genetic Variation	[4]
TMC1	OTHYH8MU	Strong	Biomarker	[5]
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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
3	A phenotype intermediate between Desbuquois dysplasia and diastrophic dysplasia secondary to mutations in DTDST.Am J Med Genet A. 2008 Nov 15;146A(22):2920-4. doi: 10.1002/ajmg.a.32543.
4	The mechanosensory structure of the hair cell requires clarin-1, a protein encoded by Usher syndrome III causative gene.J Neurosci. 2012 Jul 11;32(28):9485-98. doi: 10.1523/JNEUROSCI.0311-12.2012.
5	Publisher Correction: Improved TMC1 gene therapy restores hearing and balance in mice with genetic inner ear disorders.Nat Commun. 2019 Feb 8;10(1):734. doi: 10.1038/s41467-019-08716-x.