Details of Disease

General Information of Disease (ID: DISD1F1J)

Disease Name	Nocturia
Synonyms	sleep enuresis; enuresis, nocturnal; bedwetting
Disease Class	MF55: Polyuria
Definition	Urination during sleep.\|See genetic heterogeneity of OMIM 600631.
Disease Hierarchy	DISOTCOX: Enuresis DISD1F1J: Nocturia
ICD Code	ICD-11 ICD-11: MF55 ICD-10 ICD-10: R35 Expand ICD-11 'MF55 Expand ICD-10 'R35
Disease Identifiers	MONDO ID MONDO_0000022 MESH ID D053206 UMLS CUI C0270327 OMIM ID 600631 MedGen ID 124355 HPO ID HP:0010677 SNOMED CT ID 8009008

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Desmopressin	DMS3GVE	Approved	Small molecular drug	[1]
Flavoxate	DMKV4NL	Approved	Small molecular drug	[2]
Imipramine	DM2NUH3	Approved	Small molecular drug	[3]
Vasopressin	DMQ2FPC	Approved	Small molecular drug	[4]
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This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ASP-7035	DMTF24A	Phase 2	NA	[5]
VA-106483	DM1ODP6	Phase 2	Small molecular drug	[6]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
DRD4	TTE0A2F	Limited	Genetic Variation	[7]
AVPR2	TTK8R02	Strong	Biomarker	[8]
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This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AMY1A	OT6G4B8O	Strong	Biomarker	[9]
MIXL1	OT584VOQ	Strong	Genetic Variation	[10]
AQP2	OTQLBKK6	Definitive	Biomarker	[11]
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References

1	Desmopressin FDA Label
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3	Imipramine FDA Label
4	Vasopressin FDA Label
5	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030285)
6	ClinicalTrials.gov (NCT01038843) Efficacy Study of VA106483 in Males With Nocturia.. U.S. National Institutes of Health.
7	Effect of DRD4 receptor -616 C/G polymorphism on brain structure and functional connectivity density in pediatric primary nocturnal enuresis patients.Sci Rep. 2017 Apr 27;7(1):1226. doi: 10.1038/s41598-017-01403-1.
8	Urinary concentration: different ways to open and close the tap.Pediatr Nephrol. 2014 Aug;29(8):1297-303. doi: 10.1007/s00467-013-2526-4. Epub 2013 Jun 6.
9	Adenotonsillectomy can decrease enuresis and sympathetic nervous activity in children with obstructive sleep apnea syndrome.J Pediatr Urol. 2017 Feb;13(1):41.e1-41.e8. doi: 10.1016/j.jpurol.2016.10.009. Epub 2016 Nov 9.
10	Modified U-Shaped ileal neobladder designed for facilitating neobladder-urethral anastomosis in extracorporeal reconstruction after robotic-assisted radical cystectomy.J Cancer Res Ther. 2019 Mar;15(Supplement):S51-S55. doi: 10.4103/jcrt.JCRT_538_17.
11	Evaluation of Urinary Aquaporin 2 and Plasma Copeptin as Biomarkers of Effectiveness of Desmopressin Acetate for the Treatment of Monosymptomatic Nocturnal Enuresis.J Urol. 2017 Oct;198(4):921-927. doi: 10.1016/j.juro.2017.04.088. Epub 2017 Apr 28.