Details of the Drug

General Information of Drug (ID: DMS3GVE)

Drug Name
Desmopressin
Synonyms
Ddavp; DESMOPRESSIN; DDAVP; dAVP; Minirin; Adiuretin SD; Noctiva; Adiuretin; Deamino Arginine Vasopressin; Desmopressinum; deamino-vasopressin; [deamino1]AVP; Desmopressin [INN:BAN]; [deamino-Cys1]AVP; Desmopressinum [INN-Latin]; Desmopressine [INN-French]; Desmopresina [INN-Spanish]; Vasopressin, 1-(3-mercaptopropanoic acid)-8-D-arginine-; desnopressin; Vasopressin, Deamino Arginine; EINECS 240-726-7; 1-Desamino-8-D-arginine vasopressin; Desamino-8-D-arginine vasopressin, l-; Deamino-8-D-arginine, l-, vasopressin; Desmopressin Melt; Minrin Melt; FE-992026; Desmopressin (fast-dissolving, nocturia/diabetes insipidus); Desmopressin (fast-dissolving, nocturia/diabetes insipidus), Ferring Pharmaceuticals
Indication
Disease Entry ICD 11 Status REF
Diabetic complication 5A2Y Approved [1]
Haemophilia A 3B10.0 Approved [2]
Nocturia MF55 Approved [2]
Von willebrand disease 3B12 Approved [2]
Affected Organisms
Humans and other mammals
ATC Code
H01BA02: Desmopressin
H01BA: Vasopressin and analogues
H01B: POSTERIOR PITUITARY LOBE HORMONES
H01: PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
H: SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H01BA02: Desmopressin
H01BA: Vasopressin and analogues
H01B: POSTERIOR PITUITARY LOBE HORMONES
H01: PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
H: SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H01BA02: Desmopressin
H01BA: Vasopressin and analogues
H01B: POSTERIOR PITUITARY LOBE HORMONES
H01: PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
H: SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H01BA02: Desmopressin
H01BA: Vasopressin and analogues
H01B: POSTERIOR PITUITARY LOBE HORMONES
H01: PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
H: SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL
#Ro5 Violations (Lipinski): 5 Molecular Weight (mw) 1069.2
Logarithm of the Partition Coefficient (xlogp) -4
Rotatable Bond Count (rotbonds) 19
Hydrogen Bond Donor Count (hbonddonor) 13
Hydrogen Bond Acceptor Count (hbondacc) 15
ADMET Property
Absorption Tmax
The time to maximum plasma concentration (Tmax) is 1 h [3]
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 3: high solubility and low permeability [4]
Bioavailability
The bioavailability of drug is 90-100% [3]
Clearance
The drug present in the plasma can be removed from the body at the rate of 1.4 mL/min/kg [5]
Elimination
About 65% of oral dose is recovered in the urine within 24 hours [6]
Half-life
The concentration or amount of drug in body reduced by one-half in 2.8 hours [6]
Metabolism
The drug is metabolized via the liver [6]
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.0000254 micromolar/kg/day [7]
Vd
The volume of distribution (Vd) of drug is 0.2-0.32 L/kg [6]
Chemical Identifiers
Formula
C46H64N14O12S2
IUPAC Name
(2S)-N-[(2R)-1-[(2-amino-2-oxoethyl)amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-1-[(4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]pyrrolidine-2-carboxamide
Canonical SMILES
C1C[C@H](N(C1)C(=O)[C@@H]2CSSCCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CC(=O)N)CCC(=O)N)CC3=CC=CC=C3)CC4=CC=C(C=C4)O)C(=O)N[C@H](CCCN=C(N)N)C(=O)NCC(=O)N
InChI
InChI=1S/C46H64N14O12S2/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52)/t28-,29+,30+,31+,32+,33+,34+/m1/s1
InChIKey
NFLWUMRGJYTJIN-PNIOQBSNSA-N
Cross-matching ID
PubChem CID
5311065
ChEBI ID
CHEBI:4450
CAS Number
16679-58-6
UNII
ENR1LLB0FP
DrugBank ID
DB00035
TTD ID
D0U7SH
VARIDT ID
DR01209
Repurposed Drugs (RPD) Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Oxytocin receptor (OTR) TTSCIUP OXYR_HUMAN Agonist [8]
Vasopressin receptor (VR) TTYCILE NOUNIPROTAC Modulator [9]
Vasopressin V1a receptor (V1AR) TT4TFGN V1AR_HUMAN Agonist [8]
Vasopressin V1b receptor (V1BR) TTL9MHW V1BR_HUMAN Agonist [8]
Vasopressin V2 receptor (V2R) TTK8R02 V2R_HUMAN Agonist [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Cystic fibrosis transmembrane conductance regulator (CFTR) OT6B22QH CFTR_HUMAN Gene/Protein Processing [10]
von Willebrand factor OTNMMA2P VWF_HUMAN Gene/Protein Processing [11]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Molecular Expression Atlas of This Drug

The Studied Disease Diabetic complication
ICD Disease Classification 5A2Y
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Vasopressin V1b receptor (V1BR) DTT AVPR1B 5.14E-01 -0.03 -0.15
Molecular Expression Atlas (MEA) Jump to Detail Molecular Expression Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Disease Different from Desmopressin (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Oliceridine DM6MDCF Moderate Increased risk of hyponatremia by the combination of Desmopressin and Oliceridine. Acute pain [MG31] [12]
Budesonide DMJIBAW Major Increased risk of hyponatremia by the combination of Desmopressin and Budesonide. Asthma [CA23] [13]
Desipramine DMT2FDC Moderate Increased risk of hyponatremia by the combination of Desmopressin and Desipramine. Attention deficit hyperactivity disorder [6A05] [14]
Lamotrigine DM8SXYG Moderate Increased risk of hyponatremia by the combination of Desmopressin and Lamotrigine. Bipolar disorder [6A60] [14]
Loperamide DMOJZQ9 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Loperamide. Bowel habit change [ME05] [12]
Phenylbutazone DMAYL0T Moderate Increased risk of hyponatremia by the combination of Desmopressin and Phenylbutazone. Chronic pain [MG30] [15]
Dihydrocodeine DMB0FWL Moderate Increased risk of hyponatremia by the combination of Desmopressin and Dihydrocodeine. Chronic pain [MG30] [16]
Ketoprofen DMRKXPT Moderate Increased risk of hyponatremia by the combination of Desmopressin and Ketoprofen. Chronic pain [MG30] [14]
Morphine DMRMS0L Moderate Increased risk of hyponatremia by the combination of Desmopressin and Morphine. Chronic pain [MG30] [12]
Levomilnacipran DMV26S8 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Levomilnacipran. Chronic pain [MG30] [14]
Alfentanil DMVO0UB Moderate Increased risk of hyponatremia by the combination of Desmopressin and Alfentanil. Corneal disease [9A76-9A78] [12]
Remifentanil DMZTXCH Moderate Increased risk of hyponatremia by the combination of Desmopressin and Remifentanil. Corneal disease [9A76-9A78] [12]
Methadone DMTW6IU Moderate Increased risk of hyponatremia by the combination of Desmopressin and Methadone. Cough [MD12] [12]
Sertraline DM0FB1J Moderate Increased risk of hyponatremia by the combination of Desmopressin and Sertraline. Depression [6A70-6A7Z] [14]
Trimipramine DM1SC8M Moderate Increased risk of hyponatremia by the combination of Desmopressin and Trimipramine. Depression [6A70-6A7Z] [14]
Imipramine DM2NUH3 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Imipramine. Depression [6A70-6A7Z] [14]
Fluoxetine DM3PD2C Moderate Increased risk of hyponatremia by the combination of Desmopressin and Fluoxetine. Depression [6A70-6A7Z] [14]
Nortriptyline DM4KDYJ Moderate Increased risk of hyponatremia by the combination of Desmopressin and Nortriptyline. Depression [6A70-6A7Z] [14]
Vilazodone DM4LECQ Moderate Increased risk of hyponatremia by the combination of Desmopressin and Vilazodone. Depression [6A70-6A7Z] [14]
Paroxetine DM5PVQE Moderate Increased risk of hyponatremia by the combination of Desmopressin and Paroxetine. Depression [6A70-6A7Z] [14]
Vortioxetine DM6F1PU Moderate Increased risk of hyponatremia by the combination of Desmopressin and Vortioxetine. Depression [6A70-6A7Z] [14]
Duloxetine DM9BI7M Moderate Increased risk of hyponatremia by the combination of Desmopressin and Duloxetine. Depression [6A70-6A7Z] [14]
Milnacipran DMBFE74 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Milnacipran. Depression [6A70-6A7Z] [14]
Escitalopram DMFK9HG Moderate Increased risk of hyponatremia by the combination of Desmopressin and Escitalopram. Depression [6A70-6A7Z] [14]
Desvenlafaxine DMHD4PE Moderate Increased risk of hyponatremia by the combination of Desmopressin and Desvenlafaxine. Depression [6A70-6A7Z] [14]
Clomipramine DMINRKW Moderate Increased risk of hyponatremia by the combination of Desmopressin and Clomipramine. Depression [6A70-6A7Z] [14]
Amitriptyline DMK7F9S Moderate Increased risk of hyponatremia by the combination of Desmopressin and Amitriptyline. Depression [6A70-6A7Z] [14]
Amoxapine DMKITQE Moderate Increased risk of hyponatremia by the combination of Desmopressin and Amoxapine. Depression [6A70-6A7Z] [14]
Mirtazapine DML53ZJ Moderate Increased risk of hyponatremia by the combination of Desmopressin and Mirtazapine. Depression [6A70-6A7Z] [14]
Protriptyline DMNHTZI Moderate Increased risk of hyponatremia by the combination of Desmopressin and Protriptyline. Depression [6A70-6A7Z] [14]
Doxepin DMPI98T Moderate Increased risk of hyponatremia by the combination of Desmopressin and Doxepin. Depression [6A70-6A7Z] [14]
Maprotiline DMPWB7T Moderate Increased risk of hyponatremia by the combination of Desmopressin and Maprotiline. Depression [6A70-6A7Z] [14]
Fluvoxamine DMQTJSX Moderate Increased risk of hyponatremia by the combination of Desmopressin and Fluvoxamine. Depression [6A70-6A7Z] [14]
Venlafaxine DMR6QH0 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Venlafaxine. Depression [6A70-6A7Z] [14]
Citalopram derivative 1 DMITX1G Moderate Increased risk of hyponatremia by the combination of Desmopressin and Citalopram derivative 1. Discovery agent [N.A.] [14]
Felbamate DM1V5ZS Moderate Increased risk of hyponatremia by the combination of Desmopressin and Felbamate. Epilepsy/seizure [8A61-8A6Z] [14]
Oxcarbazepine DM5PU6O Moderate Increased risk of hyponatremia by the combination of Desmopressin and Oxcarbazepine. Epilepsy/seizure [8A61-8A6Z] [14]
Carbamazepine DMZOLBI Moderate Increased risk of hyponatremia by the combination of Desmopressin and Carbamazepine. Epilepsy/seizure [8A61-8A6Z] [14]
Eslicarbazepine DMZREFQ Moderate Increased risk of hyponatremia by the combination of Desmopressin and Eslicarbazepine. Epilepsy/seizure [8A61-8A6Z] [14]
Ethacrynic acid DM60QMR Major Increased risk of hyponatremia by the combination of Desmopressin and Ethacrynic acid. Essential hypertension [BA00] [17]
Mefenamic acid DMK7HFI Moderate Increased risk of hyponatremia by the combination of Desmopressin and Mefenamic acid. Female pelvic pain [GA34] [14]
Furosemide DMMQ8ZG Major Increased risk of hyponatremia by the combination of Desmopressin and Furosemide. Heart failure [BD10-BD1Z] [13]
Bumetanide DMRV7H0 Major Increased risk of hyponatremia by the combination of Desmopressin and Bumetanide. Heart failure [BD10-BD1Z] [13]
Torasemide DMXKJ6C Major Increased risk of hyponatremia by the combination of Desmopressin and Torasemide. Heart failure [BD10-BD1Z] [17]
Clofibrate DMPC1J7 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Clofibrate. Hyper-lipoproteinaemia [5C80] [14]
Methyldopa DM5I621 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Methyldopa. Hypertension [BA00-BA04] [14]
Enalapril DMNFUZR Moderate Increased risk of hyponatremia by the combination of Desmopressin and Enalapril. Hypertension [BA00-BA04] [14]
Fludrocortisone DMUDIR8 Major Increased risk of hyponatremia by the combination of Desmopressin and Fludrocortisone. Hypo-osmolality/hyponatraemia [5C72] [13]
Meclofenamic acid DM05FXR Moderate Increased risk of hyponatremia by the combination of Desmopressin and Meclofenamic acid. Inflammatory spondyloarthritis [FA92] [18]
Vincristine DMINOX3 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Vincristine. Mature B-cell lymphoma [2A85] [14]
Deflazacort DMV0RNS Major Increased risk of hyponatremia by the combination of Desmopressin and Deflazacort. Muscular dystrophy [8C70] [13]
Urea DMUK75B Moderate Increased risk of hyponatremia by the combination of Desmopressin and Urea. Oesophagitis [DA24] [14]
Levomethadyl Acetate DM06HG5 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Levomethadyl Acetate. Opioid use disorder [6C43] [16]
Rofecoxib DM3P5DA Moderate Increased risk of hyponatremia by the combination of Desmopressin and Rofecoxib. Osteoarthritis [FA00-FA05] [14]
Valdecoxib DMAY7H4 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Valdecoxib. Osteoarthritis [FA00-FA05] [14]
Diclofenac DMPIHLS Moderate Increased risk of hyponatremia by the combination of Desmopressin and Diclofenac. Osteoarthritis [FA00-FA05] [14]
Naproxen DMZ5RGV Moderate Increased risk of hyponatremia by the combination of Desmopressin and Naproxen. Osteoarthritis [FA00-FA05] [14]
Pentazocine DM1XBHS Moderate Increased risk of hyponatremia by the combination of Desmopressin and Pentazocine. Pain [MG30-MG3Z] [12]
Dextropropoxyphene DM23HCX Moderate Increased risk of hyponatremia by the combination of Desmopressin and Dextropropoxyphene. Pain [MG30-MG3Z] [16]
Butorphanol DM5KYPJ Moderate Increased risk of hyponatremia by the combination of Desmopressin and Butorphanol. Pain [MG30-MG3Z] [12]
Oxymorphone DM65AGJ Moderate Increased risk of hyponatremia by the combination of Desmopressin and Oxymorphone. Pain [MG30-MG3Z] [12]
Etodolac DM6WJO9 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Etodolac. Pain [MG30-MG3Z] [14]
Ibuprofen DM8VCBE Moderate Increased risk of hyponatremia by the combination of Desmopressin and Ibuprofen. Pain [MG30-MG3Z] [14]
Nabumetone DMAT2XH Moderate Increased risk of hyponatremia by the combination of Desmopressin and Nabumetone. Pain [MG30-MG3Z] [14]
Levorphanol DMGS80V Moderate Increased risk of hyponatremia by the combination of Desmopressin and Levorphanol. Pain [MG30-MG3Z] [12]
Hydromorphone DMHP21E Moderate Increased risk of hyponatremia by the combination of Desmopressin and Hydromorphone. Pain [MG30-MG3Z] [12]
Dezocine DMJDB0Y Moderate Increased risk of hyponatremia by the combination of Desmopressin and Dezocine. Pain [MG30-MG3Z] [12]
Codeine DMJX6ZG Moderate Increased risk of hyponatremia by the combination of Desmopressin and Codeine. Pain [MG30-MG3Z] [12]
Nalbuphine DMOSQGU Moderate Increased risk of hyponatremia by the combination of Desmopressin and Nalbuphine. Pain [MG30-MG3Z] [12]
Buprenorphine DMPRI8G Moderate Increased risk of hyponatremia by the combination of Desmopressin and Buprenorphine. Pain [MG30-MG3Z] [12]
Hydrocodone DMQ2JO5 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Hydrocodone. Pain [MG30-MG3Z] [12]
Tramadol DMRQD04 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Tramadol. Pain [MG30-MG3Z] [12]
Piroxicam DMTK234 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Piroxicam. Pain [MG30-MG3Z] [14]
Meperidine DMX4GND Moderate Increased risk of hyponatremia by the combination of Desmopressin and Meperidine. Pain [MG30-MG3Z] [12]
Oxycodone DMXLKHV Moderate Increased risk of hyponatremia by the combination of Desmopressin and Oxycodone. Pain [MG30-MG3Z] [12]
Prednisone DM2HG4X Major Increased risk of hyponatremia by the combination of Desmopressin and Prednisone. Postoperative inflammation [1A00-CA43] [13]
Betamethasone DMAHJEF Major Increased risk of hyponatremia by the combination of Desmopressin and Betamethasone. Postoperative inflammation [1A00-CA43] [13]
Hydrocortisone DMGEMB7 Major Increased risk of hyponatremia by the combination of Desmopressin and Hydrocortisone. Postoperative inflammation [1A00-CA43] [13]
Ketorolac DMI4EL5 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Ketorolac. Postoperative inflammation [1A00-CA43] [14]
Bromfenac DMKB79O Moderate Increased risk of hyponatremia by the combination of Desmopressin and Bromfenac. Postoperative inflammation [1A00-CA43] [14]
Ciclesonide DM2NA4K Major Increased risk of hyponatremia by the combination of Desmopressin and Ciclesonide. Respiratory system disease [CB40-CB7Z] [13]
Meloxicam DM2AR7L Moderate Increased risk of hyponatremia by the combination of Desmopressin and Meloxicam. Rheumatoid arthritis [FA20] [14]
Sulindac DM2QHZU Moderate Increased risk of hyponatremia by the combination of Desmopressin and Sulindac. Rheumatoid arthritis [FA20] [14]
Celecoxib DM6LOQU Moderate Increased risk of hyponatremia by the combination of Desmopressin and Celecoxib. Rheumatoid arthritis [FA20] [14]
Oxaprozin DM9UB0P Moderate Increased risk of hyponatremia by the combination of Desmopressin and Oxaprozin. Rheumatoid arthritis [FA20] [14]
Flurbiprofen DMGN4BY Moderate Increased risk of hyponatremia by the combination of Desmopressin and Flurbiprofen. Rheumatoid arthritis [FA20] [14]
Fenoprofen DML5VQ0 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Fenoprofen. Rheumatoid arthritis [FA20] [14]
Dexamethasone DMMWZET Major Increased risk of hyponatremia by the combination of Desmopressin and Dexamethasone. Rheumatoid arthritis [FA20] [13]
Indomethacin DMSC4A7 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Indomethacin. Rheumatoid arthritis [FA20] [14]
Tolmetin DMWUIJE Moderate Increased risk of hyponatremia by the combination of Desmopressin and Tolmetin. Rheumatoid arthritis [FA20] [14]
Haloperidol DM96SE0 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Haloperidol. Schizophrenia [6A20] [14]
Chlorpromazine DMBGZI3 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Chlorpromazine. Schizophrenia [6A20] [14]
Fentanyl DM8WAHT Moderate Increased risk of hyponatremia by the combination of Desmopressin and Fentanyl. Sensation disturbance [MB40] [12]
Sufentanil DMU7YEL Moderate Increased risk of hyponatremia by the combination of Desmopressin and Sufentanil. Sensation disturbance [MB40] [12]
Methylprednisolone DM4BDON Major Increased risk of hyponatremia by the combination of Desmopressin and Methylprednisolone. Solid tumour/cancer [2A00-2F9Z] [13]
Cyclophosphamide DM4O2Z7 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Cyclophosphamide. Solid tumour/cancer [2A00-2F9Z] [14]
Vinblastine DM5TVS3 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Vinblastine. Solid tumour/cancer [2A00-2F9Z] [14]
Ifosfamide DMCT3I8 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Ifosfamide. Solid tumour/cancer [2A00-2F9Z] [14]
Prednisolone DMQ8FR2 Major Increased risk of hyponatremia by the combination of Desmopressin and Prednisolone. Solid tumour/cancer [2A00-2F9Z] [13]
Cisplatin DMRHGI9 Moderate Increased risk of hyponatremia by the combination of Desmopressin and Cisplatin. Solid tumour/cancer [2A00-2F9Z] [14]
Vinorelbine DMVXFYE Moderate Increased risk of hyponatremia by the combination of Desmopressin and Vinorelbine. Solid tumour/cancer [2A00-2F9Z] [14]
Chlorpropamide DMPHZQE Moderate Increased risk of hyponatremia by the combination of Desmopressin and Chlorpropamide. Type 2 diabetes mellitus [5A11] [14]
Triamcinolone DM98IXF Major Increased risk of hyponatremia by the combination of Desmopressin and Triamcinolone. Vasomotor/allergic rhinitis [CA08] [13]
Fluticasone DMGCSVF Major Increased risk of hyponatremia by the combination of Desmopressin and Fluticasone. Vasomotor/allergic rhinitis [CA08] [13]
Flunisolide DMZSWQC Major Increased risk of hyponatremia by the combination of Desmopressin and Flunisolide. Vasomotor/allergic rhinitis [CA08] [13]
⏷ Show the Full List of 105 DDI Information of This Drug

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2182).
2 Desmopressin FDA Label
3 FDA Approved Drug Products: RAZADYNE (galantamine hydrobromide), for oral use
4 BDDCS applied to over 900 drugs
5 Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds
6 UKPAR for Desmopressin acetate 100mcg and 200mcg Tablets
7 Estimating the safe starting dose in phase I clinical trials and no observed effect level based on QSAR modeling of the human maximum recommended daily dose
8 Design of potent and selective agonists for the human vasopressin V1b receptor based on modifications of [deamino-cys1]arginine vasopressin at position 4. J Med Chem. 2004 Apr 22;47(9):2375-88.
9 Vasopressin V2 (SR121463A) and V1a (SR49059) receptor antagonists both inhibit desmopressin vasorelaxing activity. Eur J Pharmacol. 1999 Nov 3;383(3):287-90.
10 Vasotocin and vasopressin stimulation of the chloride secretion in the human bronchial epithelial cell line, 16HBE14o-. Br J Pharmacol. 2005 Apr;144(8):1037-50. doi: 10.1038/sj.bjp.0706103.
11 Uremic plasma after infusion of desmopressin (DDAVP) improves the interaction of normal platelets with vessel subendothelium. J Lab Clin Med. 1989 Jul;114(1):36-42.
12 Sarret D, Le Berre JP, Zemraoui N "Tramadol-induced hyponatremia." Am J Kidney Dis 52 (2008): 1026 author reply 1027. [PMID: 18971023]
13 Product Information. Stimate (desmopressin). Forest Pharmaceuticals, St. Louis, MO.
14 Cerner Multum, Inc. "Australian Product Information.".
15 Vanhees SL, Paridaens R, Vansteenkiste JF "Syndrome of inappropriate antidiuretic hormone associated with chemotherapy-induced tumour lysis in small-cell lung cancer: case report and literature review." Ann Oncol 11 (2000): 1061-5. [PMID: 11038047]
16 Appel WC "Possible roles of normeperidine and hyponatremia in a postoperative death." Can Med Assoc J 137 (1987): 912-3. [PMID: 3676934]
17 Product Information. Nocdurna (desmopressin). Ferring Inc, North York, ON.
18 Kosmidis HV, Bouhoutsou DO, Varvoutsi MC, et al. "Vincristine overdose: experience with 3 patients." Pediatr Hematol Oncol 8 (1991): 171-8. [PMID: 1863543]