Details of Disease

General Information of Disease (ID: DISDG09E)

• Disease Name: Amnesia
• Synonyms: amnesic syndrome; amnestic syndrome; amnesia; Korsakoff's psychosis or syndrome
• Disease Class: MB21: Cognition symptoms/signs/clinical sympton
• Definition: Systematic and extensive loss of memory caused by organic or psychological factors. The loss may be temporary or permanent, and may involve old or recent memories.
• Disease Hierarchy:
  DISH2ERD: Cognitive impairment
  DISDG09E: Amnesia
• ICD Code:
  ICD-11: ICD-11: MB21.1
  ICD-10: ICD-10: R41, R41.3
  Expand ICD-11: 'MB21.1
  Expand ICD-10: 'R41; 'R41.3
• Disease Identifiers:
  MONDO ID: MONDO_0001152
  MESH ID: D000647
  UMLS CUI: C0002625
  MedGen ID: 1882
  SNOMED CT ID: 3298001

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Choline alfoscerate	DMOI1ZF	Approved	Small molecular drug	[1]
Lypressin	DM154EB	Approved	Small molecular drug	[2]

This Disease is Treated as An Indication in 4 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Vinconate	DMSGF8W	Discontinued in Preregistration	Small molecular drug	[3]
ABIO-08-01	DM6Q7SO	Discontinued in Phase 2	NA	[4]
ABS-401	DMNFI36	Terminated	NA	[5]
U-80816	DMGUMWP	Terminated	NA	[6]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
BCHE	TT3MSAO	Strong	Biomarker	[7]
DRD3	TT4C8EA	Strong	Biomarker	[8]
GJA1	TT4F7SL	Strong	Biomarker	[9]
HRH3	TT9JNIC	Strong	Biomarker	[10]
HTR7	TTO9X1H	Strong	Biomarker	[11]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2172).
• [3] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001466)
• [4] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003900)
• [5] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010365)
• [6] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001336)
• [7] Effects of a new synthetic butyrylcholinesterase inhibitor, HBU-39, on cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus in a scopolamine-induced amnesia animal model.Neurochem Int. 2011 Oct;59(5):722-8. doi: 10.1016/j.neuint.2011.06.021. Epub 2011 Jul 13.
• [8] Dopamine D3 receptor antagonists improve the learning performance in memory-impaired rats.Psychopharmacology (Berl). 2005 May;179(3):567-75. doi: 10.1007/s00213-004-2096-z. Epub 2004 Dec 24.
• [9] Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala.FASEB J. 2012 Sep;26(9):3649-57. doi: 10.1096/fj.11-198416. Epub 2012 Jun 4.
• [10] Structurally novel histamine H3 receptor antagonists GSK207040 and GSK334429 improve scopolamine-induced memory impairment and capsaicin-induced secondary allodynia in rats.Biochem Pharmacol. 2007 Apr 15;73(8):1182-94. doi: 10.1016/j.bcp.2007.01.007. Epub 2007 Jan 7.
• [11] Effects of 5-HT drugs in prefrontal cortex during memory formation and the ketamine amnesia-model.Hippocampus. 2008;18(9):965-74. doi: 10.1002/hipo.20459.