Details of Disease

General Information of Disease (ID: DISDY0OZ)

Disease Name	Botulism
Synonyms	foodborne botulism (subtype); infant botulism (subtype); foodborne botulism; wound botulism (subtype); food poisoning due to Clostridium botulinum; intoxication with Clostridium botulinum toxin; botulism; infection due to Clostridium botulinum; botulism poisoning
Disease Class	1A11: Botulism
Definition	A serious bacterial infection caused by botulinum toxin which is produced by Clostridium botulinum. Patients are infected usually by ingestion of contaminated food or wound contamination. It leads to muscle paralysis which may result in respiratory failure.
Disease Hierarchy	DISKYOX0: Clostridium infection DIS8ZVFW: Primary bacterial infectious disease DISEM33Q: Infectious disease DISDY0OZ: Botulism
ICD Code	ICD-11 ICD-11: 1A11 ICD-10 ICD-10: A05.1 Expand ICD-11 '1A11 Expand ICD-10 'A05.1 Expand ICD-9 005.1,040.41,040.42
Disease Identifiers	MONDO ID MONDO_0005498 MESH ID D001906 UMLS CUI C0006057 MedGen ID 14204 Orphanet ID 1267 SNOMED CT ID 398565003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Benzylpenicillin	DMS9503	Phase 3	Small molecular drug	[1]
Botulinum neurotoxin vaccine	DMVAO8A	Phase 1	NA	[2]
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This Disease is Treated as An Indication in 1 Preclinical Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Botulinum toxin recombinant vaccine	DMEVIZS	Preclinical	NA	[3]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

References

1	Clinical Serum Therapy: Benefits, Cautions, and Potential Applications. Keio J Med. 2017 Dec 25;66(4):57-64.
2	The receptor binding domain of botulinum neurotoxin serotype A (BoNT/A) inhibits BoNT/A and BoNT/E intoxications in vivo. Clin Vaccine Immunol. 2013 Aug;20(8):1266-73.
3	Preclinical safety assessment of recombinant botulinum vaccine A/B (rBV A/B). Vaccine. 2012 Mar 2;30(11):1917-26.