Details of Disease

General Information of Disease (ID: DISE52WH)

Disease Name Intestinal obstruction
Synonyms bowel obstruction
Definition Blockage of the normal flow of the intestinal contents within the bowel.
Disease Hierarchy
DISGPMUQ: Intestinal disorder
DISE52WH: Intestinal obstruction
Disease Identifiers
MONDO ID
MONDO_0004565
MESH ID
D007415
UMLS CUI
C0021843
MedGen ID
43933
HPO ID
HP:0005214
SNOMED CT ID
81060008

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 7 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CLCA1 TT3AF4R Strong Biomarker [1]
EDNRB TT3ZTGU Strong Biomarker [2]
GUCY2C TTLDPRG Strong Biomarker [3]
RET TT4DXQT Strong Biomarker [4]
SLC26A9 TTKRVU0 Strong Biomarker [5]
SLC6A14 TTB6H2S Strong Biomarker [5]
SLC9A3 TTFZVPO Strong Biomarker [5]
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⏷ Show the Full List of 7 DTT(s)
This Disease Is Related to 4 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ACSBG1 OTM040MW Strong Biomarker [6]
GUCA2B OTZERX04 Strong Biomarker [3]
RAPH1 OTMQXW7S Strong Biomarker [6]
TREH OTJE0NOY Strong Altered Expression [7]
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References

1 Association of the CLCA1 p.S357N variant with meconium ileus in European patients with cystic fibrosis.J Pediatr Gastroenterol Nutr. 2010 Mar;50(3):347-9. doi: 10.1097/MPG.0b013e3181afce6c.
2 Long segment and short segment familial Hirschsprung's disease: variable clinical expression at the RET locus.J Med Genet. 1994 Aug;31(8):602-6. doi: 10.1136/jmg.31.8.602.
3 Synthesis of phenylpyrimidinones as guanylyl cyclase C inhibitors.Pharmazie. 2019 Jan 1;74(1):15-17. doi: 10.1691/ph.2019.8775.
4 RET and GDNF gene scanning in Hirschsprung patients using two dual denaturing gel systems.Hum Mutat. 2000;15(5):418-29. doi: 10.1002/(SICI)1098-1004(200005)15:5<418::AID-HUMU3>3.0.CO;2-2.
5 Multiple apical plasma membrane constituents are associated with susceptibility to meconium ileus in individuals with cystic fibrosis.Nat Genet. 2012 May;44(5):562-9. doi: 10.1038/ng.2221.
6 Indolent T-cell lymphoproliferative disease with synchronous diffuse large B-cell lymphoma: A case report.Medicine (Baltimore). 2019 Apr;98(17):e15323. doi: 10.1097/MD.0000000000015323.
7 Amniotic fluid microvillar enzyme activity in fetal malformations.Clin Genet. 1990 Nov;38(5):340-5. doi: 10.1111/j.1399-0004.1990.tb03592.x.