Details of Disease

Disease Name

Cholecystitis

gallstone cholecystitis; acalculous cholecystitis; chronic cholecystitis; acute on chronic cholecystitis; acute cholecystitis; inflammation of gall bladder; gall bladder inflammation; acute and chronic cholecystitis

Definition

An acute or chronic inflammation involving the gallbladder wall. It may be associated with the presence of gallstones.

Disease Hierarchy

DISWD40R: Disease

DIS9U3YN: Cholangitis

DISA6W3T: Gallbladder disease

DISG024R: Cholecystitis

Disease Identifiers

MONDO ID

MONDO_0002155

MESH ID

D002764

UMLS CUI

C0008325

MedGen ID

920

HPO ID

HP:0001082

SNOMED CT ID

76581006

General Information of Disease (ID: DISG024R)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Doripenem	DM9UCJK	Approved	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
ABCB4	TTJUXV6	Strong	Genetic Variation	[2]
GLP2R	TT1YWO5	Strong	Genetic Variation	[3]
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This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SSBP2	OTYG1G80	Limited	Posttranslational Modification	[4]
AGA	OTNWT1WB	Strong	Genetic Variation	[5]
OPN1MW	OTPJ7LX4	Strong	Biomarker	[6]
ABCG8	OTIJ76XW	Definitive	Altered Expression	[7]
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References

1	Doripenem FDA Label
2	Diagnosis of monogenic liver diseases in childhood by next-generation sequencing.Clin Genet. 2018 Mar;93(3):665-670. doi: 10.1111/cge.13120. Epub 2017 Dec 12.
3	New Avenues in the Regulation of Gallbladder Motility-Implications for the Use of Glucagon-Like Peptide-Derived Drugs.J Clin Endocrinol Metab. 2019 Jul 1;104(7):2463-2472. doi: 10.1210/jc.2018-01008.
4	Global and gene-specific DNA methylation pattern discriminates cholecystitis from gallbladder cancer patients in Chile.Future Oncol. 2015;11(2):233-49. doi: 10.2217/fon.14.165. Epub 2014 Jul 28.
5	Small for gestational age as an independent risk factor for long-term pediatric gastrointestinal morbidity of the offspring().J Matern Fetal Neonatal Med. 2019 May;32(9):1407-1411. doi: 10.1080/14767058.2017.1406473. Epub 2017 Dec 4.
6	Predicting the difficult laparoscopic cholecystectomy: development and validation of a pre-operative risk score using an objective operative difficulty grading system.Surg Endosc. 2020 Oct;34(10):4549-4561. doi: 10.1007/s00464-019-07244-5. Epub 2019 Nov 15.
7	Variants in ABCG8 and TRAF3 genes confer risk for gallstone disease in admixed Latinos with Mapuche Native American ancestry.Sci Rep. 2019 Jan 28;9(1):772. doi: 10.1038/s41598-018-35852-z.