Details of Disease

General Information of Disease (ID: DISG6CM2)

Disease Name	Rift valley fever
Synonyms	RVF
Disease Class	1D44: Rift valley fever
Definition	Rift Valley fever (RVF), caused by the Rift Valley fever virus (RVFV), is an arbovirus characterized by a usually self-limiting febrile illness but that in some cases can also manifest with thrombosis, vision loss, hemorrhages and/or neurological symptoms.
Disease Hierarchy	DISGFCIX: Vector-borne disease DISQEBTU: Viral hemorrhagic fever DISG6CM2: Rift valley fever
ICD Code	ICD-11 ICD-11: 1D44 ICD-10 ICD-10: A92.4 Expand ICD-11 '1D44 Expand ICD-10 'A92.4
Disease Identifiers	MONDO ID MONDO_0017880 MESH ID D012295 UMLS CUI C0035613 MedGen ID 20589 Orphanet ID 319251 SNOMED CT ID 402917003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
MP-12	DMWT4L8	Phase 2	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
FBXO3	TTUX14L	Strong	Biomarker	[2]
TICAM1	TT2GQT6	Strong	Genetic Variation	[3]
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This Disease Is Related to 7 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
GTF2H2	OTK72L9I	Strong	Altered Expression	[2]
GTF2H3	OT87W5QJ	Strong	Altered Expression	[2]
GTF2H5	OTRL219S	Strong	Altered Expression	[2]
NUDT16	OTWSL9JQ	Strong	Altered Expression	[4]
POLD4	OTG578YH	Strong	Genetic Variation	[5]
POLE4	OTCMWUT6	Strong	Genetic Variation	[5]
TRIM69	OTTEGTRD	Strong	Genetic Variation	[3]
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⏷ Show the Full List of 7 DOT(s)

References

1	ClinicalTrials.gov (NCT00415051) Safety/Immunogenicity/Genetic Drift of MP-12 Rift Valley Fever Vaccine. U.S. National Institutes of Health.
2	Virulence factor NSs of rift valley fever virus recruits the F-box protein FBXO3 to degrade subunit p62 of general transcription factor TFIIH.J Virol. 2014 Mar;88(6):3464-73. doi: 10.1128/JVI.02914-13. Epub 2014 Jan 8.
3	Association of symptoms and severity of rift valley fever with genetic polymorphisms in human innate immune pathways.PLoS Negl Trop Dis. 2015 Mar 10;9(3):e0003584. doi: 10.1371/journal.pntd.0003584. eCollection 2015 Mar.
4	Virus-induced translational arrest through 4EBP1/2-dependent decay of 5'-TOP mRNAs restricts viral infection.Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2920-9. doi: 10.1073/pnas.1418805112. Epub 2015 May 18.
5	Ability of a mutagenized virus variant to protect young lambs from Rift Valley fever.Am J Vet Res. 1991 Jan;52(1):50-5.