Details of Disease

General Information of Disease (ID: DISGZDUO)

• Disease Name: Otitis media
• Synonyms: middle ear inflammation; otitis Media; middle Ear Inflammation; otitis media (disease); medial otitis; inflammation of middle ear
• Disease Class: AA80-AB0Z: Otitis media
• Definition: Inflammation of the anatomical structures of the middle ear, which is most often caused by an infectious process. Symptoms include erythema and edema of the tympanic membrane, pain, and possibly fever.
• Disease Hierarchy:
  DIS184KT: Skin inflammation
  DISWD40R: Disease
  DISGPS1R: Middle ear disorder
  DISGZDUO: Otitis media
• ICD Code:
  ICD-11: ICD-11: AA80-AB0Z
  ICD-10: ICD-10: H66.9
  Expand ICD-11: 'AB0Z
  Expand ICD-10: 'H66.9
• Disease Identifiers:
  MONDO ID: MONDO_0005441
  MESH ID: D010033
  UMLS CUI: C0029882
  MedGen ID: 45253
  HPO ID: HP:0000388
  SNOMED CT ID: 65363002

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Boric acid	DMYOCTP	Approved	Small molecular drug	[1]
Morniflumate	DM9UTDE	Approved	Small molecular drug	[1]
Pneumovax 23	DMIR2US	Approved	Small molecular drug	[1]
Prevnar	DMQ0C2Z	Approved	Vaccine	[1]

This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
BAY-35-3377	DMWYPZF	Phase 3	Small molecular drug	[2]
OP-145	DMQLXKK	Phase 2	Peptide	[3]
bis-triazole derivative 10	DMN2EI1	Clinical trial	Small molecular drug	[4]

This Disease is Treated as An Indication in 4 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
2085-P	DM0GMJ6	Discontinued in Phase 3	Small molecular drug	[5]
MLI-1018	DMGE1KQ	Terminated	NA	[6]
OtiVax	DMZRGWF	Terminated	NA	[7]
SPD-703	DMA9XN2	Terminated	NA	[8]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
P-13	DMPGPOY	Investigative	Small molecular drug	[9]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 19 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
DEFB4A	TTIVY12	Limited	Biomarker	[10]
MUC5AC	TTEL90S	moderate	Altered Expression	[11]
BPI	TTXCSDR	Strong	Genetic Variation	[12]
CTSB	TTF2LRI	Strong	Biomarker	[13]
CTSK	TTDZN01	Strong	Biomarker	[13]
CTSL	TT36ETB	Strong	Biomarker	[13]
CXCR4	TTBID49	Strong	Biomarker	[14]
ENPP1	TTZTIWS	Strong	Biomarker	[15]
FBXO11	TT6G10V	Strong	Genetic Variation	[16]
FGFR1	TTRLW2X	Strong	Biomarker	[17]
IDUA	TT0IUKX	Strong	Biomarker	[18]
IL1A	TTPM6HI	Strong	Biomarker	[19]
MUC1	TTBHFYQ	Strong	Biomarker	[20]
NAGLU	TTDM6HZ	Strong	Biomarker	[21]
NISCH	TT789FN	Strong	Biomarker	[22]
OPHN1	TTU7HRD	Strong	Genetic Variation	[23]
PORCN	TTNFBTO	Strong	Biomarker	[24]
SCGB1A1	TTONPVW	Strong	Biomarker	[25]
SMC2	TTS8D17	Strong	Biomarker	[26]

This Disease Is Related to 39 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
MCPH1	OTYT3TT5	Limited	Biomarker	[27]
MUC5B	OTPW6K5C	Limited	Biomarker	[28]
PRX	OT34Z10B	Disputed	Genetic Variation	[29]
RSPH4A	OTNDPGEE	Disputed	Biomarker	[30]
AQP8	OT99JKME	moderate	Altered Expression	[31]
DHRS2	OTFHWIY8	moderate	Biomarker	[32]
EDARADD	OT0G52MC	moderate	Biomarker	[33]
PIP	OTH719AH	moderate	Biomarker	[34]
BPIFA1	OTQFD2J5	Strong	Biomarker	[12]
BTC	OTW4B2O0	Strong	Biomarker	[35]
C7	OTZ27VJN	Strong	Biomarker	[36]
CAPN14	OTWKW0Y6	Strong	Biomarker	[37]
CBY1	OTAKMUS2	Strong	Biomarker	[38]
CFAP97	OT0RSQO4	Strong	Biomarker	[39]
CRYGC	OTYSTQWI	Strong	Altered Expression	[40]
DNAH5	OTC21RUS	Strong	Biomarker	[41]
E2F4	OTB3JFH4	Strong	Biomarker	[42]
EYA4	OTINGR3Z	Strong	Biomarker	[43]
GALNT14	OT9BSDDQ	Strong	Biomarker	[37]
ITFG1	OTX0PCR3	Strong	Biomarker	[44]
LMNA	OT3SG7ZR	Strong	Biomarker	[45]
MECOM	OTP983W8	Strong	Biomarker	[46]
METTL8	OT7E09Y4	Strong	Biomarker	[44]
MUC4	OTLT11V1	Strong	Biomarker	[47]
PACC1	OTKBS8CC	Strong	Biomarker	[48]
PHEX	OTG7N3J7	Strong	Biomarker	[49]
POLD4	OTG578YH	Strong	Biomarker	[45]
POLE4	OTCMWUT6	Strong	Biomarker	[45]
PPP2R2D	OTCZPP0N	Strong	Biomarker	[50]
RPL38	OTFQIGL5	Strong	Biomarker	[51]
SALL4	OTC08PR5	Strong	Biomarker	[52]
SCN2B	OTFAHJ38	Strong	Biomarker	[53]
SFTPA2	OT6SFOMU	Strong	Genetic Variation	[54]
SH3PXD2B	OTAOMCDJ	Strong	Biomarker	[55]
TBX1	OTQLBPRA	Strong	Biomarker	[56]
TGIF1	OTN9VHAG	Strong	Biomarker	[57]
TIPRL	OTS2FZ8O	Strong	Biomarker	[44]
TP73	OT0LUO47	Strong	Biomarker	[58]
A2ML1	OTWNUXIS	Definitive	Biomarker	[59]

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