Details of Disease

General Information of Disease (ID: DISHQ3BE)

Disease Name Carpal tunnel syndrome
Synonyms CTS; amyotrophy, thenar, of carpal origin; CTS - carpal tunnel syndrome; median nerve entrapment; carpal tunnel median neuropathy; carpal tunnel syndrome
Definition Entrapment of the median nerve in the wrist that is characterized by numbness, tingling and painful movement.
Disease Hierarchy
DISSYRHC: Hereditary peripheral neuropathy
DIS93JJO: Nerve compression syndrome
DISHQ3BE: Carpal tunnel syndrome
Disease Identifiers
MONDO ID
MONDO_0007275
MESH ID
D002349
UMLS CUI
C0007286
MedGen ID
2856
Orphanet ID
50838
SNOMED CT ID
57406009

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Lidocaine DML4ZOT Approved Small molecular drug [1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 5 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
AOC1 TTM3B5R Limited Genetic Variation [2]
SMAD6 TTON5JB Limited Genetic Variation [2]
UMPS TTAFJUD Limited Genetic Variation [2]
ADAMTS5 TTXSU2Y Strong Altered Expression [3]
B2M TTY7FKA Strong Biomarker [4]
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This Disease Is Related to 1 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
ABCD1 DTKM9DZ Strong Biomarker [5]
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This Disease Is Related to 1 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
SULT1A3 DEP7E8X Strong Genetic Variation [6]
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This Disease Is Related to 19 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ADAMTS10 OTNJ9VSU Limited Genetic Variation [2]
ADAMTS17 OTCFITM9 Limited Genetic Variation [2]
AEBP1 OTBI1RZ6 Limited Genetic Variation [2]
EFEMP1 OTZVUOOB Limited Genetic Variation [2]
FBN2 OT3KYJQL Limited Autosomal dominant [7]
HCP5 OTV0YRI8 Limited Genetic Variation [2]
LTBP1 OTR7Q75L Limited Genetic Variation [2]
TTLL5 OTUKOVEM Limited Genetic Variation [2]
COL5A1 OT24078H Strong Genetic Variation [8]
CSH2 OTW8JVAN Strong Biomarker [9]
ERCC8 OT0T4WKI Strong Biomarker [9]
HLA-DPA1 OT7OG7Y2 Strong Genetic Variation [10]
HLA-DRB3 OT5PM9N7 Strong Genetic Variation [10]
INTU OTXB13E6 Strong Biomarker [11]
NDUFB2 OT4717TF Strong Genetic Variation [8]
PMP22 OTXWYWCZ Strong Biomarker [12]
SEMA5B OTUVSKK0 Strong Biomarker [13]
SEMG1 OT6Z4BPQ Strong Biomarker [13]
SULT1A4 OTHJ8WWV Strong Genetic Variation [6]
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⏷ Show the Full List of 19 DOT(s)

References

1 Lidocaine FDA Label
2 A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome.Nat Commun. 2019 Mar 4;10(1):1030. doi: 10.1038/s41467-019-08993-6.
3 Cryptotanshinone protects against IL-1-induced inflammation in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice.Int Immunopharmacol. 2017 Sep;50:161-167. doi: 10.1016/j.intimp.2017.06.017. Epub 2017 Jun 27.
4 Association Between Environmental Particulate Matter and Carpal Tunnel Syndrome in Patients Undergoing Hemodialysis.Kidney Blood Press Res. 2017;42(5):827-836. doi: 10.1159/000484422. Epub 2017 Nov 21.
5 Control of germination and lipid mobilization by COMATOSE, the Arabidopsis homologue of human ALDP.EMBO J. 2002 Jun 17;21(12):2912-22. doi: 10.1093/emboj/cdf300.
6 The Impact of Pre-Referral Advanced Diagnostic Testing on Wait Time to See a Hand Surgeon for Common Upper-Extremity Conditions.J Hand Surg Am. 2019 Dec;44(12):1013-1020.e2. doi: 10.1016/j.jhsa.2019.09.009. Epub 2019 Oct 31.
7 Delineation of a new fibrillin-2-opathy with evidence for a role of FBN2 in the pathogenesis of carpal tunnel syndrome. J Med Genet. 2021 Nov;58(11):778-782. doi: 10.1136/jmedgenet-2020-107085. Epub 2020 Sep 8.
8 The COL5A1 gene is associated with increased risk of carpal tunnel syndrome.Clin Rheumatol. 2015 Apr;34(4):767-74. doi: 10.1007/s10067-014-2727-7. Epub 2014 Jun 26.
9 Can ultrasound imaging be used for the diagnosis of carpal tunnel syndrome in diabetic patients? A systemic review and network meta-analysis.J Neurol. 2020 Jul;267(7):1887-1895. doi: 10.1007/s00415-019-09254-8. Epub 2019 Feb 25.
10 Some implications of genetic biomarkers in occupational epidemiology and practice.Scand J Work Environ Health. 2004 Feb;30(1):71-9. doi: 10.5271/sjweh.767.
11 Electrophysiological Assessment for Splinting in the Treatment of Carpal Tunnel Syndrome.Neurol Med Chir (Tokyo). 2017 Sep 15;57(9):472-480. doi: 10.2176/nmc.oa.2017-0075. Epub 2017 Jul 28.
12 Clinical, neurophysiological and pathological findings of HNPP patients with 17p12 deletion: a single-centre experience.J Neurol Sci. 2014 Jun 15;341(1-2):46-50. doi: 10.1016/j.jns.2014.03.046. Epub 2014 Mar 31.
13 Motor unit number index (MUNIX) derivation from the relationship between the area and power of surface electromyogram: a computer simulation and clinical study.J Neural Eng. 2018 Jun;15(3):036013. doi: 10.1088/1741-2552/aaae19. Epub 2018 Feb 9.