Details of Disease

Disease Name

Pseudotumor cerebri

intracranial hypertension, idiopathic; benign intracranial hypertension; Idiopathic Intracranial Hypertension; pseudotumor cerebri; IIH; benign intracran. hypt.; idiopathic intracranial hypertension

Definition

Idiopathic intracranial hypertension is a neurological disorder characterized by isolated increased intracranial pressure manifesting with recurrent and persistent headaches, nausea, vomiting, progressive and transient obstruction of the visual field, papilledema. Visual loss can be irreversible.

Disease Hierarchy

DISAB237: Cerebrovascular disease

DISW3FM9: Intracranial hypertension

DISLLY7S: Pseudotumor cerebri

Disease Identifiers

MONDO ID

MONDO_0009468

MESH ID

D011559

UMLS CUI

C0033845

OMIM ID

243200

MedGen ID

18732

Orphanet ID

238624

SNOMED CT ID

68267002

General Information of Disease (ID: DISLLY7S)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Mannitol	DMSCDY9	Approved	Small molecular drug	[1]
Thiopental	DMGP8AX	Approved	Small molecular drug	[2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
MOG	TTQAFX5	Strong	Genetic Variation	[3]
CXCR1	TTMWT8Z	Definitive	Genetic Variation	[4]
LAMC2	TTNS7H3	Definitive	Biomarker	[5]
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This Disease Is Related to 10 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
AQP4	OTA9MYD5	Strong	Altered Expression	[6]
SH3PXD2B	OTAOMCDJ	Strong	Genetic Variation	[7]
FAM8A1	OT1QVTGS	Definitive	Genetic Variation	[4]
FOXN3	OTOJYJZP	Definitive	Genetic Variation	[4]
PARP4	OTXBK59G	Definitive	Genetic Variation	[4]
PRH1	OTQZ6HX0	Definitive	Genetic Variation	[4]
PRR4	OT26I382	Definitive	Genetic Variation	[4]
RPH3AL	OT9VFJEL	Definitive	Genetic Variation	[4]
TAS2R14	OTWA9CYC	Definitive	Genetic Variation	[4]
TAS2R43	OT70V8MZ	Definitive	Genetic Variation	[4]
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⏷ Show the Full List of 10 DOT(s)

References

1	Mannitol FDA Label
2	Thiopental FDA Label
3	Atypical Anti-MOG syndrome with aseptic meningoencephalitis and pseudotumor cerebri-like presentations.Mult Scler Relat Disord. 2019 Jan;27:30-33. doi: 10.1016/j.msard.2018.10.003. Epub 2018 Oct 3.
4	Genetic Survey of Adult-Onset Idiopathic Intracranial Hypertension.J Neuroophthalmol. 2019 Mar;39(1):50-55. doi: 10.1097/WNO.0000000000000648.
5	Cerebrospinal fluid dynamics in pediatric pseudotumor cerebri syndrome.Childs Nerv Syst. 2020 Jan;36(1):73-86. doi: 10.1007/s00381-019-04263-4. Epub 2019 Jul 19.
6	Cerebral microvascular abnormalities in patients with idiopathic intracranial hypertension.Brain Res. 2018 May 1;1686:72-82. doi: 10.1016/j.brainres.2018.02.017. Epub 2018 Feb 22.
7	Ophthalmic findings in Frank-ter Haar syndrome: report of a sibling pair.J AAPOS. 2017 Dec;21(6):514-516. doi: 10.1016/j.jaapos.2017.07.216. Epub 2017 Oct 31.