Details of Disease

General Information of Disease (ID: DISLOSB4)

• Disease Name: Hypopharyngeal carcinoma
• Synonyms: hypopharyngeal cancer; hypopharyngeal throat cancer; cancer of the hypopharynx; cancer of hypopharynx; carcinoma of the hypopharynx; hypopharynx carcinoma; carcinoma of hypopharynx; hypopharyngeal carcinoma
• Definition: Carcinoma, predominantly squamous cell, arising from the epithelial cells of the hypopharynx.|Carcinoma, predominantly squamous cell, arising from epithelial cells of the hypopharynx
• Disease Hierarchy:
  DISW5DOZ: Hypopharynx cancer
  DISH9F1N: Carcinoma
  DISOU1DS: Head and neck carcinoma
  DISKPWNX: Carcinoma of pharynx
  DISLOSB4: Hypopharyngeal carcinoma
• Disease Identifiers:
  MONDO ID: MONDO_0005216
  UMLS CUI: C1368404
  MedGen ID: 237150

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 6 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
NGFR	TTEDJN4	Limited	Biomarker	[1]
ACACB	TTY84UG	moderate	Altered Expression	[2]
GRHL2	TTUGH4C	Strong	Biomarker	[3]
HAX1	TT21BYA	Strong	Biomarker	[4]
LYVE1	TTG8DNU	Strong	Biomarker	[5]
NSD1	TTTSJ3H	Strong	Biomarker	[6]

This Disease Is Related to 6 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CENPH	OTPOO9LK	Strong	Biomarker	[7]
GRK6	OT4LZTP9	Strong	Biomarker	[8]
HOPX	OTBSR6C9	Strong	Altered Expression	[9]
NIPBL	OTF6OOLU	Strong	Biomarker	[10]
PCDH8	OTDDOQM2	Strong	Altered Expression	[11]
RBM17	OT9ROJCL	Strong	Biomarker	[12]

References

• [1] Humanized anti-CD271 monoclonal antibody exerts an anti-tumor effect by depleting cancer stem cells.Cancer Lett. 2019 Oct 1;461:144-152. doi: 10.1016/j.canlet.2019.07.011. Epub 2019 Jul 17.
• [2] The role of acetyl-coA carboxylase2 in head and neck squamous cell carcinoma.PeerJ. 2019 Jun 11;7:e7037. doi: 10.7717/peerj.7037. eCollection 2019.
• [3] Human Papillomavirus 16 E6 Induces FoxM1B in Oral Keratinocytes through GRHL2.J Dent Res. 2018 Jul;97(7):795-802. doi: 10.1177/0022034518756071. Epub 2018 Feb 14.
• [4] Abnormal expression of HAX? is associated with cellular proliferation and migration in human hypopharyngeal squamous cell carcinoma.Mol Med Rep. 2017 Oct;16(4):4664-4670. doi: 10.3892/mmr.2017.7155. Epub 2017 Aug 3.
• [5] Association of eIF4E and SPARC Expression with Lymphangiogenesis and Lymph Node Metastasis in Hypopharyngeal Cancer.Anticancer Res. 2018 Feb;38(2):699-706. doi: 10.21873/anticanres.12275.
• [6] Whole-exome sequencing reveals novel mutations and epigenetic regulation in hypopharyngeal carcinoma.Oncotarget. 2017 Jul 28;8(49):85326-85340. doi: 10.18632/oncotarget.19674. eCollection 2017 Oct 17.
• [7] Role of centromere protein H and Ki67 in relapse-free survival of patients after primary surgery for hypopharyngeal cancer.Asian Pac J Cancer Prev. 2012;13(3):821-5. doi: 10.7314/apjcp.2012.13.3.821.
• [8] Aberrant GRK6 promoter methylation is associated with poor prognosis in hypopharyngeal squamous cell carcinoma.Oncol Rep. 2016 Feb;35(2):1027-33. doi: 10.3892/or.2015.4469. Epub 2015 Dec 1.
• [9] Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma.Br J Cancer. 2004 Jul 19;91(2):258-61. doi: 10.1038/sj.bjc.6601952.
• [10] HSV-1 Infection Modulates the Radioresponse of a HPV16-positive Head and Neck Cancer Cell Line.Anticancer Res. 2016 Feb;36(2):565-74.
• [11] Expression of protocadherin8: Function as a tumor suppressor in hypopharyngeal carcinoma.Cancer Biomark. 2018;22(3):495-502. doi: 10.3233/CBM-171137.
• [12] Downregulation of RNA binding motif protein 17 expression inhibits proliferation of hypopharyngeal carcinoma FaDu cells.Oncol Lett. 2018 Apr;15(4):5680-5684. doi: 10.3892/ol.2018.8012. Epub 2018 Feb 9.