Details of Disease

General Information of Disease (ID: DISLWJSE)

Disease Name Dense deposit disease
Synonyms MPGN 2; glomerulonephritis membranoproliferative type 2; membranoproliferative glomerulonephritis type II; membranoproliferative glomerulonephritis type 2; Mesangiocapillary glomerulonephritis type 2
Definition
Dense deposit disease, a histological subtype of MPGN is an idiopathic chronic progressive kidney disorder distinguished by the presence of intra-membranous dense deposits in addition to immune complex subendothelial deposits in the glomerular capillary walls. This form often has a higher recurrence rate after a kidney transplant and is associated with extra-renal manifestations such as familial drusen.
Disease Hierarchy
DISW087P: Primary membranoproliferative glomerulonephritis
DISLWJSE: Dense deposit disease
Disease Identifiers
MONDO ID
MONDO_0019736
MESH ID
D015432
UMLS CUI
C0268743
MedGen ID
124345
Orphanet ID
93571
SNOMED CT ID
722760002

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 4 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CFH TTUW6OP Supportive Autosomal recessive [1]
TSLP TTHMW3T moderate Biomarker [2]
CFH TTUW6OP Strong Genetic Variation [3]
PON1 TT9LX82 Strong Biomarker [4]
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This Disease Is Related to 4 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CFH OTAGKQTJ Supportive Autosomal recessive [1]
CFHR1 OT72R16T Supportive Autosomal recessive [5]
C1QA OT6XKVVA Strong Biomarker [6]
CFHR5 OT7BMOYE Strong Genetic Variation [7]
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References

1 Gene polymorphism of complement factor H in a Turkish patient with membranoproliferative glomerulonephritis type II. Iran J Kidney Dis. 2012 Mar;6(2):149-53.
2 All-trans-retinoic acid aggravates cryoglobulin-associated membranoproliferative glomerulonephritis in mice.Nephrol Dial Transplant. 2007 Dec;22(12):3451-61. doi: 10.1093/ndt/gfm502. Epub 2007 Aug 8.
3 Retinal disease in the C3 glomerulopathies and the risk of impaired vision.Ophthalmic Genet. 2016 Dec;37(4):369-376. doi: 10.3109/13816810.2015.1101777. Epub 2016 Feb 25.
4 Is paraoxonase 192 gene polymorphism a risk factor for membranoproliferative glomerulonephritis in children?. Cell Biochem Funct. 2007 Mar-Apr;25(2):159-65. doi: 10.1002/cbf.1288.
5 C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation. J Clin Invest. 2013 Jun;123(6):2434-46. doi: 10.1172/JCI68280.
6 Molecular basis of hereditary C1q deficiency associated with SLE and IgA nephropathy in a Turkish family.Kidney Int. 1996 Aug;50(2):635-42. doi: 10.1038/ki.1996.359.
7 Complement factor H related proteins (CFHRs). Mol Immunol. 2013 Dec 15;56(3):170-80. doi: 10.1016/j.molimm.2013.06.001. Epub 2013 Jul 3.