Details of Disease | DrugMAP

General Information of Disease (ID: DISNFZKJ)

Disease Name	Adrenal gland cancer
Synonyms	tumour of the adrenal gland; tumor of the adrenal gland; adrenal neoplasm; malignant tumour of the adrenal gland; malignant tumour of adrenal gland; malignant tumor of the adrenal gland; malignant tumor of adrenal gland; malignant neoplasm of the adrenal gland; malignant neoplasm of adrenal gland; malignant adrenal tumour; malignant adrenal tumor; malignant adrenal neoplasm; malignant adrenal gland tumour; malignant adrenal gland tumor; malignant adrenal gland neoplasm; cancer of adrenal gland; adrenal gland cancer; adrenal cancer
Definition	A malignant neoplasm involving the adrenal gland
Disease Hierarchy	DISAT1Z9: Advanced cancer : DISKTBM1: Malignant endocrine neoplasm DISFK7RF: Adrenal gland neoplasm DISNFZKJ: Adrenal gland cancer
Disease Identifiers	MONDO ID MONDO_0002817 MESH ID D000310 UMLS CUI C0750887 MedGen ID 152909 SNOMED CT ID 363355002

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 5 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
CDKN2A	TTFTWQ8	Strong	Biomarker	[1]
GNRH1	TT0ID4A	Strong	Therapeutic	[2]
GNRHR	TT8R70G	Strong	Biomarker	[3]
PRKACA	TT5U49F	Strong	Biomarker	[1]
TSHR	TT6NYJA	Strong	Biomarker	[3]
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This Disease Is Related to 3 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CDC42	OT5QBC5M	Strong	Biomarker	[1]
GNAS	OTMH8BKJ	Strong	Biomarker	[1]
RB1	OT9VMY7B	Strong	Biomarker	[1]
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References

1	Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors.Nat Genet. 2014 Jun;46(6):613-7. doi: 10.1038/ng.2956. Epub 2014 Apr 20.
2	Hecate-CGbeta conjugate and gonadotropin suppression shows two distinct mechanisms of action in the treatment of adrenocortical tumors in transgenic mice expressing Simian Virus 40 T antigen under inhibin-alpha promoter. Endocr Relat Cancer. 2009 Jun;16(2):549-64. doi: 10.1677/ERC-08-0232. Epub 2009 Mar 4.
3	Screening for membrane hormone receptor expression in primary aldosteronism.Eur J Endocrinol. 2009 Mar;160(3):443-51. doi: 10.1530/EJE-08-0711. Epub 2009 Jan 8.