Details of Disease

General Information of Disease (ID: DISNWVJU)

Disease Name Seborrhoeic dermatitis
Synonyms seborrhea; skin seborrheic; seborrheic dermatitis (disease); Seborrhoeic dermatitis; seborrheic eczema; seborrheic dermatitis; Seborrhoeic eczema; cradle Cap
Disease Class EA81: Seborrhoeic dermatitis
Definition A chronic, inflammatory skin disorder that affects the scalp, central face and skin folds; it is characterized by scaling and itching.
Disease Hierarchy
DISY5SZC: Dermatitis
DISNWVJU: Seborrhoeic dermatitis
ICD Code
ICD-11
ICD-11: EA81
Expand ICD-11
'EA81
Expand ICD-10
'L21; 'L21.8; 'L21.9
Disease Identifiers
MONDO ID
MONDO_0006608
MESH ID
D012628
UMLS CUI
C0036508
MedGen ID
19912
HPO ID
HP:0001051
SNOMED CT ID
50563003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Pyrithione Zinc DMNA8HM Approved Small molecular drug [1]
Salicyclic acid DM2F8XZ Approved Small molecular drug [2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
GRM3 TT8A9EF moderate Genetic Variation [3]
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This Disease Is Related to 3 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
MAST4 OT3LOE2J moderate Genetic Variation [3]
EPGN OT3EG75W Strong Altered Expression [4]
MPZL3 OTC4LRBU Strong Biomarker [5]
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References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4306).
3 The Genetics of Seborrheic Dermatitis: ACandidate Gene Approach and Pilot Genome-Wide Association Study.J Invest Dermatol. 2018 Apr;138(4):991-993. doi: 10.1016/j.jid.2017.11.020. Epub 2017 Dec 2.
4 Activation of Nrf2 in keratinocytes causes chloracne (MADISH)-like skin disease in mice.EMBO Mol Med. 2014 Apr;6(4):442-57. doi: 10.1002/emmm.201303281. Epub 2014 Feb 6.
5 Seborrheic dermatitis-Looking beyond Malassezia.Exp Dermatol. 2019 Sep;28(9):991-1001. doi: 10.1111/exd.14006. Epub 2019 Aug 19.