Details of Disease

General Information of Disease (ID: DISOWLOH)

Disease Name	Spontaneous abortion
Disease Class	JA00: Abortion
Definition	Three or more consecutive spontaneous abortions.
Disease Hierarchy	DIS7W23Z: Reproductive system disorder DISOWLOH: Spontaneous abortion
ICD Code	ICD-11 ICD-11: JA00.0
Disease Identifiers	MONDO ID MONDO_0006774 MESH ID D000026 UMLS CUI C0000809 MedGen ID 1259 SNOMED CT ID 102878001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Methylergonovine	DMBEX4O	Approved	Small molecular drug	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
SYCP3	OTKOF54H	moderate	Biomarker	[2]
CREB5	OTJDUJPI	Strong	Biomarker	[3]
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References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	Mutations of the SYCP3 gene in women with recurrent pregnancy loss.Am J Hum Genet. 2009 Jan;84(1):14-20. doi: 10.1016/j.ajhg.2008.12.002. Epub 2008 Dec 24.
3	Integrated analysis of DNA methylome and transcriptome identified CREB5 as a novel risk gene contributing to recurrent pregnancy loss.EBioMedicine. 2018 Sep;35:334-344. doi: 10.1016/j.ebiom.2018.07.042. Epub 2018 Aug 10.