Details of Disease

General Information of Disease (ID: DISPMG3Z)

Disease Name Non-proliferative diabetic retinopathy
Synonyms non-proliferative diabetic retinopathy; non proliferative diabetic retinopathy
Disease Class 9B71: Retinopathy
Definition An early stage of diabetic retinopathy that is characterized by retinal hemorrhage and exudate, but without proliferation of the blood vessels.
Disease Hierarchy
DISHGUJM: Diabetic retinopathy
DISPMG3Z: Non-proliferative diabetic retinopathy
ICD Code
ICD-11
ICD-11: 9B71.00
Disease Identifiers
MONDO ID
MONDO_0001661
UMLS CUI
C0004606
MedGen ID
2531
SNOMED CT ID
390834004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Runcaciguat DMCFTTN Phase 2 Small molecule [1]
------------------------------------------------------------------------------------

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ANGPTL3 TT59GO7 Strong Biomarker [2]
CHN2 TT39YVO Definitive Genetic Variation [3]
------------------------------------------------------------------------------------
This Disease Is Related to 4 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ANGPTL8 OTQFINCD Strong Altered Expression [4]
IL26 OT2WYCW4 Strong Altered Expression [5]
PLXNA2 OTNNBJMQ Strong Biomarker [6]
RBP3 OTIWM4GT Strong Genetic Variation [7]
------------------------------------------------------------------------------------

References

1 ClinicalTrials.gov (NCT04722991) A Phase 2 Randomized, Placebo-controlled, Double-masked Proof-of-concept Study to Investigate the Efficacy and Safety of Runcaciguat (BAY 1101042) in Patients With Moderately Severe to Severe Non-proliferative Diabetic Retinopathy. U.S.National Institutes of Health.
2 Angiopoietin-like 3 Is a Potential Biomarker for Retinopathy in Type 2 Diabetic Patients.Am J Ophthalmol. 2018 Jul;191:34-41. doi: 10.1016/j.ajo.2018.03.040. Epub 2018 Apr 3.
3 Chimerin 2 genetic polymorphisms are associated with non-proliferative diabetic retinopathy in Taiwanese type 2 diabetic patients.J Diabetes Complications. 2014 Jul-Aug;28(4):460-3. doi: 10.1016/j.jdiacomp.2014.04.009. Epub 2014 Apr 18.
4 Expression of angiopoietin-like protein 8 correlates with VEGF in patients with proliferative diabetic retinopathy.Graefes Arch Clin Exp Ophthalmol. 2017 Aug;255(8):1515-1523. doi: 10.1007/s00417-017-3676-z. Epub 2017 Apr 29.
5 Increased interleukin-26 expression in proliferative diabetic retinopathy.Int J Ophthalmol. 2019 Nov 18;12(11):1688-1692. doi: 10.18240/ijo.2019.11.04. eCollection 2019.
6 Progression of Diabetic Microaneurysms According to the Internal Reflectivity on Structural Optical Coherence Tomography and Visibility on Optical Coherence Tomography Angiography.Am J Ophthalmol. 2019 Feb;198:8-16. doi: 10.1016/j.ajo.2018.09.031. Epub 2018 Oct 9.
7 Interphotoreceptor retinoid-binding protein (IRBP) is downregulated at early stages of diabetic retinopathy.Diabetologia. 2009 Dec;52(12):2633-41. doi: 10.1007/s00125-009-1548-8. Epub 2009 Oct 13.