Details of Disease | DrugMAP

General Information of Disease (ID: DISPMZ3U)

Disease Name	Colon adenoma
Synonyms	colonic adenoma; colon adenoma; adenoma of the colon; adenoma of colon
Definition	An adenoma that arises from the colon. The group of colonic adenomas includes tubular, villous, and tubulovillous adenomas, traditional serrated adenomas, sessile serrated adenomas/polyps, and familial adenomatous polyposis.
Disease Hierarchy	DIS78ZEV: Adenoma DISTSVHM: Colorectal adenoma : DISPMZ3U: Colon adenoma
Disease Identifiers	MONDO ID MONDO_0000527 UMLS CUI C4551463 MedGen ID 1639098

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 7 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
FGFBP1	TTV1YFT	Limited	Altered Expression	[1]
AHCY	TTE2KUJ	Strong	Altered Expression	[2]
F5	TT1O264	Strong	Biomarker	[3]
FFAR2	TT0FYAN	Strong	Biomarker	[4]
TMPRSS11D	TTWHYC8	Strong	Biomarker	[5]
VANGL1	TT18WJB	Strong	Biomarker	[6]
SULF2	TTLQTHB	Definitive	Altered Expression	[7]
------------------------------------------------------------------------------------


⏷ Show the Full List of 7 DTT(s)

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ACTL6A	OT0EC5BQ	Limited	Altered Expression	[8]
PDZK1IP1	OTWA6M5K	moderate	Altered Expression	[9]
FERMT1	OT626PBA	Strong	Altered Expression	[2]
SULF1	OTJCNCO0	Definitive	Altered Expression	[7]
------------------------------------------------------------------------------------

References

1	Expression of a fibroblast growth factor-binding protein during the development of adenocarcinoma of the pancreas and colon.Cancer Res. 2006 Jan 15;66(2):1191-8. doi: 10.1158/0008-5472.CAN-05-2926.
2	Digital transcript profile analysis with aRNA-LongSAGE validates FERMT1 as a potential novel prognostic marker for colon cancer.Clin Cancer Res. 2011 May 1;17(9):2908-18. doi: 10.1158/1078-0432.CCR-10-2552. Epub 2011 Jan 10.
3	The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats.Cancer Prev Res (Phila). 2014 Nov;7(11):1160-9. doi: 10.1158/1940-6207.CAPR-14-0056. Epub 2014 Sep 8.
4	Loss of FFAR2 promotes colon cancer by epigenetic dysregulation of inflammation suppressors.Int J Cancer. 2018 Aug 15;143(4):886-896. doi: 10.1002/ijc.31366. Epub 2018 Mar 30.
5	Histone hypoacetylation contributes to CXCL12 downregulation in colon cancer: impact on tumor growth and cell migration.Oncotarget. 2017 Jun 13;8(24):38351-38366. doi: 10.18632/oncotarget.16323.
6	Elevated Coexpression of KITENIN and the ErbB4 CYT-2 Isoform Promotes the Transition from Colon Adenoma to Carcinoma Following APC loss.Clin Cancer Res. 2016 Mar 1;22(5):1284-94. doi: 10.1158/1078-0432.CCR-15-0306. Epub 2015 Nov 2.
7	SULFs in human neoplasia: implication as progression and prognosis factors.J Transl Med. 2011 May 21;9:72. doi: 10.1186/1479-5876-9-72.
8	ACTL6A expression promotes invasion, metastasis and epithelial mesenchymal transition of colon cancer.BMC Cancer. 2018 Oct 22;18(1):1020. doi: 10.1186/s12885-018-4931-3.
9	Identification of a novel gene, selectively up-regulated in human carcinomas, using the differential display technique.Clin Cancer Res. 1995 Oct;1(10):1209-15.